ha14-1 has been researched along with Lymphoma in 2 studies
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate: a BH3 mimetic; synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Importantly, low-concentration HA14-1 (5 muM) was nontoxic to normal colony-forming cells, whereas it enhanced the cytotoxicity of the antileukemia drug cytarabine in Bcl-2-positive lymphoblastic leukemia cells." | 7.72 | HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. ( Cox, J; Johnson, L; Lickliter, JD; McHugh, G; Tan, J; Wickham, NW; Wood, F; Wood, NJ, 2003) |
| " Importantly, low-concentration HA14-1 (5 muM) was nontoxic to normal colony-forming cells, whereas it enhanced the cytotoxicity of the antileukemia drug cytarabine in Bcl-2-positive lymphoblastic leukemia cells." | 3.72 | HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. ( Cox, J; Johnson, L; Lickliter, JD; McHugh, G; Tan, J; Wickham, NW; Wood, F; Wood, NJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lickliter, JD | 2 |
| Wood, NJ | 1 |
| Johnson, L | 1 |
| McHugh, G | 1 |
| Tan, J | 1 |
| Wood, F | 1 |
| Cox, J | 2 |
| Wickham, NW | 1 |
| McCarron, J | 1 |
| Martinez, NR | 1 |
| Schmidt, CW | 1 |
| Lin, H | 1 |
| Nieda, M | 1 |
| Nicol, AJ | 1 |
2 other studies available for ha14-1 and Lymphoma
| Article | Year |
|---|---|
HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death.
Topics: Apoptosis; Benzopyrans; Blast Crisis; Bone Marrow Cells; Cell Death; Cell Survival; Cytarabine; Drug | 2003 |
Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction.
Topics: Adult; Antineoplastic Agents; Benzopyrans; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; | 2007 |