ha14-1 has been researched along with Leucocythaemia in 4 studies
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate: a BH3 mimetic; synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
| Excerpt | Relevance | Reference |
|---|---|---|
| " Importantly, low-concentration HA14-1 (5 muM) was nontoxic to normal colony-forming cells, whereas it enhanced the cytotoxicity of the antileukemia drug cytarabine in Bcl-2-positive lymphoblastic leukemia cells." | 7.72 | HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. ( Cox, J; Johnson, L; Lickliter, JD; McHugh, G; Tan, J; Wickham, NW; Wood, F; Wood, NJ, 2003) |
| " Importantly, low-concentration HA14-1 (5 muM) was nontoxic to normal colony-forming cells, whereas it enhanced the cytotoxicity of the antileukemia drug cytarabine in Bcl-2-positive lymphoblastic leukemia cells." | 3.72 | HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. ( Cox, J; Johnson, L; Lickliter, JD; McHugh, G; Tan, J; Wickham, NW; Wood, F; Wood, NJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, CY | 1 |
| Park, C | 1 |
| Lee, JH | 1 |
| Chung, KT | 1 |
| Kwon, TK | 1 |
| Kim, GY | 2 |
| Choi, BT | 1 |
| Choi, YH | 2 |
| Moon, DO | 1 |
| Kim, MO | 1 |
| Kang, SH | 1 |
| Park, SY | 1 |
| Lickliter, JD | 1 |
| Wood, NJ | 1 |
| Johnson, L | 1 |
| McHugh, G | 1 |
| Tan, J | 1 |
| Wood, F | 1 |
| Cox, J | 1 |
| Wickham, NW | 1 |
| Tian, D | 1 |
| Das, SG | 1 |
| Doshi, JM | 1 |
| Peng, J | 1 |
| Lin, J | 1 |
| Xing, C | 1 |
4 other studies available for ha14-1 and Leucocythaemia
| Article | Year |
|---|---|
Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Benzopyrans; Caspase Inh | 2009 |
HA14-1 sensitizes TNF-alpha-induced apoptosis via inhibition of the NF-kappaB signaling pathway: involvement of reactive oxygen species and JNK.
Topics: Apoptosis; Benzopyrans; Cell Line, Tumor; DNA, Neoplasm; Enzyme Activation; Humans; Leukemia; MAP Ki | 2010 |
HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death.
Topics: Apoptosis; Benzopyrans; Blast Crisis; Bone Marrow Cells; Cell Death; Cell Survival; Cytarabine; Drug | 2003 |
sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Ben | 2008 |