ha14-1 has been researched along with Breast Neoplasms in 3 studies
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate: a BH3 mimetic; synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bcl-2 and Bcl-XL expression and apoptosis induction were analyzed in HER-2 gene-amplified (BT474) and nonamplified (ZR 75-1) breast cancer cell lines exposed to trastuzumab, alone or in combination with either Bcl-2/Bcl-XL bispecific antisense oligonucleotides (AS-4625) or the small-molecule Bcl-2 antagonist HA14-1." | 3.72 | Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in HER-2 gene--amplified breast cancer cells. ( Bruno, T; Cianciulli, A; Ciuffreda, L; Cognetti, F; Del Bufalo, D; Milella, M; Mottolese, M; Trisciuoglio, D; Zangemeister-Wittke, U; Zupi, G, 2004) |
| "GW2974 is a reversible dual inhibitor similar to lapatinib, but GW2974 was not progressed to clinical trials due to pharmacokinetic issues." | 1.34 | Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor. ( Berger, M; Lipton, A; Planas-Silva, MD; Viallet, J; Witkoski, A; Witters, LM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arisan, ED | 1 |
| Kutuk, O | 1 |
| Tezil, T | 1 |
| Bodur, C | 1 |
| Telci, D | 1 |
| Basaga, H | 1 |
| Milella, M | 1 |
| Trisciuoglio, D | 1 |
| Bruno, T | 1 |
| Ciuffreda, L | 1 |
| Mottolese, M | 1 |
| Cianciulli, A | 1 |
| Cognetti, F | 1 |
| Zangemeister-Wittke, U | 1 |
| Del Bufalo, D | 1 |
| Zupi, G | 1 |
| Witters, LM | 1 |
| Witkoski, A | 1 |
| Planas-Silva, MD | 1 |
| Berger, M | 1 |
| Viallet, J | 1 |
| Lipton, A | 1 |
3 other studies available for ha14-1 and Breast Neoplasms
| Article | Year |
|---|---|
Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Asso | 2010 |
Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in HER-2 gene--amplified breast cancer cells.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; bcl-X P | 2004 |
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzopyrans; Breast Neoplasms | 2007 |