ha 1004 has been researched along with Muscle Contraction in 7 studies
N-(2-guanidinoethyl)-5-isoquinolinesulfonamide: structure given in first source
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "HA 1004 is a calcium antagonist vasodilator that inhibits contraction in vascular smooth muscle and lowers arterial blood pressure." | 1.27 | Antibronchoconstrictor activity of the intracellular calcium antagonist HA 1004 in guinea pigs. ( Chapman, RW; Kreutner, W; Tozzi, S, 1988) |
| " HA-1004 shifted the dose-response curve for CaCl2 to the right in a competitive manner in depolarized rabbit renal arterial strips." | 1.27 | Relaxation of vascular smooth muscle by HA-1004, an inhibitor of cyclic nucleotide-dependent protein kinase. ( Hidaka, H; Inagaki, M; Ishikawa, T; Watanabe, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McKenna, TM | 1 |
| Clegg, JM | 1 |
| Williams, TJ | 1 |
| Horio, S | 1 |
| Fukui, H | 1 |
| Chapman, RW | 1 |
| Tozzi, S | 1 |
| Kreutner, W | 1 |
| Ishikawa, T | 1 |
| Inagaki, M | 2 |
| Watanabe, M | 1 |
| Hidaka, H | 4 |
| Tanaka, T | 1 |
| Ashoori, F | 1 |
| Tomita, T | 1 |
| Asano, T | 1 |
1 review available for ha 1004 and Muscle Contraction
| Article | Year |
|---|---|
[Molecular pharmacology on intracellular calcium messenger system].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actomyosin; Binding Sites; Calcium; Calcium Channel B | 1986 |
6 other studies available for ha 1004 and Muscle Contraction
| Article | Year |
|---|---|
Protein kinase C is a mediator of lipopolysaccharide-induced vascular suppression in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; | 1994 |
Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium; Enzyme Inhibitors; G | 2001 |
Antibronchoconstrictor activity of the intracellular calcium antagonist HA 1004 in guinea pigs.
Topics: Animals; Bronchodilator Agents; Calcium Channel Blockers; Guinea Pigs; Hemodynamics; Histamine H1 An | 1988 |
Relaxation of vascular smooth muscle by HA-1004, an inhibitor of cyclic nucleotide-dependent protein kinase.
Topics: Adenosine Triphosphatases; Animals; Atropine; Calcimycin; Calcium Chloride; Cyclic AMP; Cyclic GMP; | 1985 |
Carbachol-induced contraction in the circular muscle of guinea-pig stomach in calcium-free solution.
Topics: Animals; Calcium; Calmodulin; Carbachol; Dose-Response Relationship, Drug; Female; Guinea Pigs; In V | 1986 |
Intracellular Ca++ antagonist, HA1004: pharmacological properties different from those of nicardipine.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Coronary Circulation; Dogs; Heart Ventricles; | 1985 |