h-89 and Vascular-Calcification

Vascular calcification (VC) is a marker of the severity of atherosclerotic disease. Hormones play important roles in regulating calcification; estrogen and parathyroid hormones exert opposing effects, the former alleviating VC and the latter exacerbating it. To date no treatment strategies have been developed to regulate clinical VC.. The objective of this study was to investigate the effect of growth hormone-releasing hormone (GHRH) and its agonist (GHRH-A) on the blocking of VC in a mouse model.. GHRH-A controls osteogenesis in smooth muscle cells by targeting cross talk between protein kinase A and nuclear factor κB (p65) and through the suppression of reactive oxygen species production that induces the

Topics: Alkaline Phosphatase; Animals; Aorta; Core Binding Factor Alpha 1 Subunit; Culture Media; Cyclic AMP-Dependent Protein Kinases; Growth Hormone-Releasing Hormone; Heart Transplantation; Humans; Isoquinolines; Mice; Mice, Inbred C57BL; Osteogenesis; Osteoprotegerin; Peptide Fragments; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone; RNA, Small Interfering; Sulfonamides; Transcription Factor RelA; Vascular Calcification