gyy-4137 has been researched along with Chronic-Disease* in 1 studies
1 other study(ies) available for gyy-4137 and Chronic-Disease
| Article | Year |
|---|---|
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy.
Chronic obstructive uropathy can cause irreversible kidney injury, atrophy and inflammation, which can ultimately lead to fibrosis. Epithelial-mesenchymal transition is a key trigger of fibrosis that is caused by up-regulation of TGF-β1 (transforming growth factor-β1) and ANGII (angiotensin II). H. Following unilateral ureteral obstruction male Lewis rats were given daily intraperitoneal administration of phosphate buffered saline vehicle (obstruction group) or phosphate buffered saline plus 200 μmol/kg GYY4137 (obstruction plus GYY4137 group) for 30 days. Urine and serum samples were collected to determine physiological parameters of renal function and injury. Kidneys were removed on postoperative day 30 to evaluate histopathology and protein expression. Epithelial-mesenchymal transition in LLC-PK1 pig kidney epithelial cells was induced with TGF-β1 and treated with GYY4137 to evaluate potential mechanisms via in vitro scratch wound assays.. H. To our knowledge our findings demonstrate for the first time the protective effects of H Topics: Animals; Chronic Disease; Hydrogen Sulfide; Kidney Diseases; Male; Morpholines; Organothiophosphorus Compounds; Rats; Rats, Inbred Lew; Swine; Ureteral Obstruction | 2016 |