gypenoside-ix and Chemical-and-Drug-Induced-Liver-Injury--Chronic

Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.

Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Drugs, Chinese Herbal; Hypolipidemic Agents; Liver Cirrhosis, Experimental; Male; Poisons; Rats; Rats, Wistar; Saponins