gypenoside-ix and Brain-Ischemia

To observe the protective effect of gypenosides (GP) on the neurons of hippocampus, cerebral cortex, corpus striatum, and dentate gyrus in cerebral ischemia-reperfusion injury of rats.. Modified 4-vessel occlusion (4-VO) method was used to establish the model of acute global ischemia. The acridine orange (AO) staining method was used to observe the DNA and RNA contents of cerebral ischemia-reperfusion injury model in the areas.. The fluorescent intensity (reflecting DNA and RNA contents) of the DNA and RNA in the areas of cerebral ischemia-reperfusion injury was markedly abated compared with the normal control group. In the group of ig GP (100 mg/kg) it was enhanced compared with the model group and was the same as the normal control group.. The injury of the DNA and RNA in the areas of ischemia-reperfusion model was decreased by GP.

Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Cucurbitaceae; DNA; Drugs, Chinese Herbal; Male; Neurons; Neuroprotective Agents; Plants, Medicinal; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; RNA; Saponins