gyki 52466 has been researched along with Seizures in 48 studies
GYKI 52466: an AMPA (non-NMDA) receptor antagonist; structure given in first source
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous studies have shown a local decrease in glutamate and aspartate levels during seizures, induced by picrotoxin microdialysis in the hippocampus of chronic freely moving rats." | 7.70 | Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats. ( Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD, 2000) |
| "A competitive (NBQX) and a non-competitive (GYKI 52466) AMPA antagonist, and a competitive NMDA antagonist (D-CPPene) were tested against the development of kindling and against fully kindled seizures in amygdala-kindled rats." | 7.69 | The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures. ( Craggs, M; Dürmüller, N; Meldrum, BS, 1994) |
| "GYKI 52466 was effective in prolonging the latency to generalised seizures and reduction of seizure mortality." | 5.35 | Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. ( Krisztin-Péva, B; Mihály, A; Weiczner, R, 2008) |
| " Daily repeated epileptic seizures were induced for 12 days by intraperitoneal administration of 4-aminopyridine (4-AP; 4." | 3.75 | Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. ( Bakos, M; Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Szucs, B; Világi, I; Vincze, A, 2009) |
| " The new compounds proved to protect against seizures induced by means of auditory stimulation in DBA/2 mice and some of them showed anticonvulsant properties comparable or better than those of GYKI 52466, the prototype of 2,3-benzodiazepine noncompetitive AMPA receptor antagonists." | 3.72 | Synthesis and anticonvulsant activity of N-3 substituted 2,3-benzodiazepines. ( Caruso, R; Chimirri, A; De Sarro, G; Orlando, V; Quartarone, S; Russo, E, 2004) |
| "In this study, we evaluated whether beta-adrenoceptor antagonists may modify the protective efficacy of dizocilpine (MK-801), a NMDA receptor antagonist, and 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466), a non-NMDA (AMPA/kainate) receptor antagonist, against maximal electroshock-induced seizures in mice." | 3.71 | beta-Adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock. ( Kleinrok, Z; Luchowska, E; Luchowski, P; Urbanska, EM; Wielosz, M, 2001) |
| " The evaluation is reported of their anticonvulsant effects, both in the audiogenic seizures test with DBA/2 mice and against the maximal electroshock- and pentylenetetrazole-induced seizures in Swiss mice." | 3.70 | 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists. ( Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Libri, V; Quartarone, S; Zappalà, M, 1998) |
| "We have previously shown that 1-aryl-3,5-dihydro-7, 8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) possess marked anticonvulsant properties and antagonize seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) in analogy to the structurally related 1-(4-aminophenyl)-4-methyl-7, 8-methylenedioxy-5H-2,3-benzodiazepine (1, GYKI 52466), a well-known noncompetitive AMPA/kainate receptor antagonist." | 3.70 | Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M, 1999) |
| " The new compounds were found to possess anticonvulsant effects against seizures induced both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.70 | Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones. ( Bevacqua, F; Chimirri, A; De Sarro, A; De Sarro, G; Gitto, R; Quartarone, S; Rizzo, M; Zappalà, M, 2000) |
| "Our previous studies have shown a local decrease in glutamate and aspartate levels during seizures, induced by picrotoxin microdialysis in the hippocampus of chronic freely moving rats." | 3.70 | Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats. ( Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD, 2000) |
| " The seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.69 | 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. ( Chapman, AG; Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Giusti, P; Grasso, S; Libri, V; Quartarone, S; Zappalà, M, 1997) |
| "A competitive (NBQX) and a non-competitive (GYKI 52466) AMPA antagonist, and a competitive NMDA antagonist (D-CPPene) were tested against the development of kindling and against fully kindled seizures in amygdala-kindled rats." | 3.69 | The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures. ( Craggs, M; Dürmüller, N; Meldrum, BS, 1994) |
| "Aminophylline reversed the protective action of both, D-3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid (D-CPP-ene-a competitive NMDA antagonist) and valproate (used as a conventional antiepileptic drug for comparative purposes) against maximal electroshock-induced seizures." | 3.69 | Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, WA; Tutka, P, 1996) |
| " GYKI 52466 was also protective against seizures and lethality induced by 4-aminopyridine, kainate and AMPA, but not by NMDA, whereas NBQX was ineffective in these chemoconvulsant tests." | 3.68 | Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. ( Donevan, SD; Rogawski, MA; Yamaguchi, S, 1993) |
| " Mice withdrawn from chronic treatment with diazepam showed a time-related evolution of anxiety, muscle rigidity, and seizures between days 4 and 21 after treatment discontinuation." | 3.68 | Diazepam dependence prevented by glutamate antagonists. ( Steppuhn, KG; Turski, L, 1993) |
| "The excitatory amino acid antagonists, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline) and GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine) that act on non-NMDA receptors, provide potent anticonvulsant protection against AMPA [RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-induced seizures in Swiss mice and against sound-induced seizures in seizure-susceptible DBA/2 mice." | 3.68 | The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. ( Chapman, AG; Meldrum, BS; Smith, SE, 1991) |
| "As generation of the two types of seizures is concerned, NMDA and AMPA participate in generalized tonic-clonic seizures whereas NMDA receptors play a dominant role in generation of flexion seizures." | 1.51 | Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats? ( Folbergrová, J; Haugvicová, R; Kubová, H; Mareš, P, 2019) |
| "We conclude that reactive astrocytosis and activation of glutamate release from astrocyte processes might contribute, together with increased reactive oxygen species production, to the vulnerability to kainate excitotoxicity in Dach-SMO mice." | 1.43 | Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. ( Berretta, N; Cecconi, F; Cervelli, M; Cervetto, C; D'Amelio, M; Marcoli, M; Mariottini, P; Maura, G; Mercuri, N; Passalacqua, M; Ragazzoni, M; Venturini, A; Vergani, L; Voci, A, 2016) |
| "Effects of repetitive seizures on ionotropic glutamate receptors (iGluRs) were investigated in rat entorhinal cortex slices." | 1.42 | Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors. ( Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Világi, I, 2015) |
| "GYKI 52466 was effective in prolonging the latency to generalised seizures and reduction of seizure mortality." | 1.35 | Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. ( Krisztin-Péva, B; Mihály, A; Weiczner, R, 2008) |
| "Sound-induced seizure testing showed that this class of compounds possessed anticonvulsant properties." | 1.32 | Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist. ( Barreca, ML; Chimirri, A; Constanti, A; De Luca, L; De Sarro, G; Ferreri, G; Gitto, R; Quartarone, S; Russo, E, 2003) |
| "Compound 21 also effectively suppresses seizures induced in Swiss mice by maximal electroshock (MES) and pentylenetetrazole (PTZ)." | 1.31 | Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M, 2000) |
| "Furthermore, it antagonized in vivo seizures induced by icv administration of AMPA or kainate (KA)." | 1.31 | Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters. ( De Micheli, C; De Sarro, A; De Sarro, G; Ferreri, G; Grasso, S; Micale, N; Puja, G; Toma, L; Zappalà, M, 2002) |
| "There was a commensurate reduction in seizure-related neuronal loss in the limbic regions of the brain." | 1.31 | In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466. ( Lees, GJ; Leong, W, 2001) |
| "The inhibition of seizure evoked by maximal electroshock was also found to be remarkable: the ED(50) values of GYKI 52466 and its two analogues were 6." | 1.31 | Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. ( Gacsályi, I; Gigler, G; Gyertyán, I; Lévay, G; Szabados, T, 2001) |
| "at its CD97 of 90 mg/kg) convulsions." | 1.30 | GYKI 52466 [1-(4-aminophenyl)-4-methoxy-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the anticonvulsive activity of conventional antiepileptics against pentetrazol in mice. ( Czuczwar, SJ; Gasior, M; Kamiński, R; Kleinrok, Z; Kozicka, M; Ossowska, G; Pietrasiewicz, T, 1998) |
| "K+ channel blockers are known to induce seizures, but the specific K channel types that can serve as convulsant targets are not well defined." | 1.30 | Induction of seizures by the potent K+ channel-blocking scorpion venom peptide toxins tityustoxin-K(alpha) and pandinustoxin-K(alpha). ( Blaustein, MP; Juhng, KN; Kim, BY; Kokate, TG; Rogawski, MA; Rogowski, RS; Yamaguchi, S, 1999) |
| "1." | 1.29 | Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil. ( Hönack, D; Löscher, W, 1994) |
| "1S,3R-ACPD-induced seizures were antagonized by systemic administration of dantrolene, an inhibitor of intracellular calcium mobilization, but not by the ionotropic glutamate antagonists MK-801 or GYKI-52466." | 1.29 | Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. ( Fix, AS; McDonald, JW; Schoepp, DD; Tizzano, JP, 1993) |
| "Pretreatment with aniracetam (50 nmol i." | 1.29 | Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice. ( al-Zubaidy, Z; Chapman, AG; Meldrum, BS, 1993) |
| "In some cases more efficient seizure protection was not associated with increased adverse effects." | 1.29 | Influence of combined treatment with NMDA and non-NMDA receptor antagonists on electroconvulsions in mice. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Turski, WA; Tutka, P; Zarnowski, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (43.75) | 18.2507 |
| 2000's | 21 (43.75) | 29.6817 |
| 2010's | 6 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chimirri, A | 10 |
| De Sarro, G | 14 |
| De Sarro, A | 8 |
| Gitto, R | 10 |
| Grasso, S | 6 |
| Quartarone, S | 8 |
| Zappalà, M | 8 |
| Giusti, P | 1 |
| Libri, V | 2 |
| Constanti, A | 3 |
| Chapman, AG | 3 |
| Wang, Y | 1 |
| Konkoy, CS | 1 |
| Ilyin, VI | 1 |
| Vanover, KE | 1 |
| Carter, RB | 1 |
| Weber, E | 1 |
| Keana, JF | 1 |
| Woodward, RM | 1 |
| Cai, SX | 1 |
| Micale, N | 5 |
| Puia, G | 1 |
| Baraldi, M | 2 |
| De Micheli, C | 4 |
| Puja, G | 2 |
| Bevacqua, F | 1 |
| Rizzo, M | 1 |
| Ferreri, G | 4 |
| Toma, L | 1 |
| Barreca, ML | 2 |
| De Luca, L | 3 |
| Russo, E | 4 |
| Zuccalà, G | 1 |
| Menniti, FS | 1 |
| Caruso, R | 3 |
| Pagano, B | 3 |
| Citraro, R | 3 |
| Costa, L | 1 |
| Ciranna, L | 1 |
| Scicchitano, F | 1 |
| Malik, S | 1 |
| Bahare, RS | 1 |
| Khan, SA | 1 |
| Mareš, P | 1 |
| Folbergrová, J | 1 |
| Haugvicová, R | 1 |
| Kubová, H | 1 |
| Shtaya, A | 1 |
| Sadek, AR | 1 |
| Zaben, M | 1 |
| Seifert, G | 1 |
| Pringle, A | 1 |
| Steinhäuser, C | 1 |
| Gray, WP | 1 |
| Borbély, S | 2 |
| Czégé, D | 2 |
| Molnár, E | 2 |
| Dobó, E | 2 |
| Mihály, A | 3 |
| Világi, I | 3 |
| Cervetto, C | 1 |
| Vergani, L | 1 |
| Passalacqua, M | 1 |
| Ragazzoni, M | 1 |
| Venturini, A | 1 |
| Cecconi, F | 1 |
| Berretta, N | 1 |
| Mercuri, N | 1 |
| D'Amelio, M | 1 |
| Maura, G | 1 |
| Mariottini, P | 1 |
| Voci, A | 1 |
| Marcoli, M | 1 |
| Cervelli, M | 1 |
| Bakos, M | 1 |
| Szucs, B | 1 |
| Vincze, A | 1 |
| Nayak, PK | 1 |
| Kerr, DS | 1 |
| Orlando, V | 3 |
| De Sarro, GB | 1 |
| Cheung, EC | 1 |
| Melanson-Drapeau, L | 1 |
| Cregan, SP | 1 |
| Vanderluit, JL | 1 |
| Ferguson, KL | 1 |
| McIntosh, WC | 1 |
| Park, DS | 1 |
| Bennett, SA | 1 |
| Slack, RS | 1 |
| Gressens, P | 1 |
| Spedding, M | 1 |
| Gigler, G | 2 |
| Kertesz, S | 1 |
| Villa, P | 1 |
| Medja, F | 1 |
| Williamson, T | 1 |
| Kapus, G | 2 |
| Levay, G | 2 |
| Szenasi, G | 1 |
| Barkoczy, J | 1 |
| Harsing, LG | 2 |
| Lasztóczi, B | 1 |
| Kardos, J | 1 |
| Weiczner, R | 1 |
| Krisztin-Péva, B | 1 |
| Yamaguchi, S | 2 |
| Donevan, SD | 1 |
| Rogawski, MA | 2 |
| Löscher, W | 1 |
| Hönack, D | 1 |
| Dürmüller, N | 1 |
| Craggs, M | 1 |
| Meldrum, BS | 3 |
| McDonald, JW | 2 |
| Schoepp, DD | 2 |
| Steppuhn, KG | 1 |
| Turski, L | 1 |
| Fix, AS | 1 |
| Tizzano, JP | 1 |
| al-Zubaidy, Z | 1 |
| Czuczwar, SJ | 4 |
| Borowicz, KK | 1 |
| Kleinrok, Z | 5 |
| Tutka, P | 2 |
| Zarnowski, T | 1 |
| Turski, WA | 2 |
| Gasior, M | 2 |
| Borowicz, K | 1 |
| Starownik, R | 1 |
| Kamiński, R | 1 |
| Kozicka, M | 1 |
| Ossowska, G | 1 |
| Pietrasiewicz, T | 1 |
| Juhng, KN | 1 |
| Kokate, TG | 1 |
| Kim, BY | 1 |
| Rogowski, RS | 1 |
| Blaustein, MP | 1 |
| Min, MY | 1 |
| Melyan, Z | 1 |
| Kullmann, DM | 1 |
| Dóczi, J | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Barna, B | 1 |
| Pouw, B | 1 |
| Nour, M | 1 |
| Matsumoto, RR | 1 |
| Sierra-Paredes, G | 1 |
| Galán-Valiente, J | 1 |
| Vazquez-Illanes, MD | 1 |
| Aguilar-Veiga, E | 1 |
| Sierra-Marcuño, G | 1 |
| Abrahám, G | 1 |
| Sólyom, S | 1 |
| Csuzdi, E | 1 |
| Berzsenyi, P | 1 |
| Ling, I | 1 |
| Tarnawa, I | 1 |
| Hámori, T | 1 |
| Pallagi, I | 1 |
| Horváth, K | 1 |
| Andrási, F | 1 |
| Király, I | 1 |
| Patthy, M | 1 |
| Horváth, G | 1 |
| Lees, GJ | 1 |
| Leong, W | 1 |
| Szabados, T | 1 |
| Gacsályi, I | 1 |
| Gyertyán, I | 1 |
| Luchowska, E | 1 |
| Luchowski, P | 1 |
| Wielosz, M | 1 |
| Urbanska, EM | 1 |
| Smith, SE | 1 |
48 other studies available for gyki 52466 and Seizures
| Article | Year |
|---|---|
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
Synthesis of 7,8-(methylenedioxy)-1-phenyl-3,5-dihydro-4H-2, 3-benzodiazepin-4-ones as novel and potent noncompetitive AMPA receptor antagonists.
Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Benzodiazepines; Cer | 1998 |
3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1998 |
7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiet | 1998 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; | 1999 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 2000 |
Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones.
Topics: Acoustic Stimulation; Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2000 |
Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cerebellum; Dioxoles; Excitatory Amino Acid Antagoni | 2002 |
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Isoquinolines; Li | 2003 |
1-aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Drug Design; Mice; Models, Molecula | 2003 |
Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; In Vitro Techniques; Isoquinolines; Male; Mice; Mice | 2006 |
Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists.
Topics: Animals; Anticonvulsants; Isoquinolines; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Struct | 2008 |
Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides.
Topics: Animals; Anticonvulsants; Isoquinolines; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Se | 2009 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, | 2013 |
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzodiazepines; Dizocilpine Maleate; Homocysteine; Male; Quin | 2019 |
AMPA receptors and seizures mediate hippocampal radial glia-like stem cell proliferation.
Topics: Animals; Animals, Newborn; Benzodiazepines; Cell Death; Cell Proliferation; Cells, Cultured; Excitat | 2018 |
Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Benzodiazepines; Entorhinal Cortex; Excitator | 2015 |
Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.
Topics: Animals; Aspartic Acid; Astrocytes; Benzodiazepines; Biogenic Polyamines; Calcium; Cerebral Cortex; | 2016 |
Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Animals; Benzodiazepines; Biophysic | 2009 |
Low-dose GYKI-52466: prophylactic preconditioning confers long-term neuroprotection and functional recovery following hypoxic-ischaemic brain injury.
Topics: Animals; Benzodiazepines; Brain; Carotid Artery Diseases; Carotid Artery, Common; Disease Models, An | 2013 |
Synthesis and pharmacological properties of new 3-ethoxycarbonyl-11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Drug Evaluation, Preclinical; Mice; | 2002 |
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Evaluation, Preclinical; Excitato | 2004 |
Synthesis and anticonvulsant activity of N-3 substituted 2,3-benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Mice; Mice, Inbred DBA; Receptors, A | 2004 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Fac | 2005 |
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cell Survival; C | 2005 |
Cyclothiazide prolongs low [Mg2+]-induced seizure-like events.
Topics: 4-Aminopyridine; Animals; Benzodiazepines; Benzothiadiazines; Diuretics; Excitatory Amino Acid Antag | 2006 |
Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Benzodiazepines; Brain | 2008 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Age | 1993 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship | 1994 |
The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Electric Stimulation; Kin | 1994 |
Aminooxyacetic acid produces excitotoxic brain injury in neonatal rats.
Topics: Aminooxyacetic Acid; Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain; Corpus | 1993 |
Diazepam dependence prevented by glutamate antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Tolerance; Electroencephalography; Ele | 1993 |
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain Injuries; Cell Nucleus; Corpu | 1993 |
Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Dose-Response | 1993 |
Influence of combined treatment with NMDA and non-NMDA receptor antagonists on electroconvulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Drug Combinations; Electroshock; Mal | 1995 |
Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice.
Topics: Aminophylline; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Convulsants; Electros | 1996 |
Anticonvulsant and adverse effects of MK-801, LY 235959, and GYKI 52466 in combination with Ca2+ channel inhibitors in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Benzodiazepines; Calcium Channel | 1997 |
GYKI 52466 [1-(4-aminophenyl)-4-methoxy-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the anticonvulsive activity of conventional antiepileptics against pentetrazol in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Benzodiazepines; Convulsants; Dru | 1998 |
Induction of seizures by the potent K+ channel-blocking scorpion venom peptide toxins tityustoxin-K(alpha) and pandinustoxin-K(alpha).
Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dizo | 1999 |
Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; GABA-B | 1999 |
Effect of a glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices.
Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Electric Stimulatio | 1999 |
Effects of AMPA/kainate glutamate receptor antagonists on cocaine-induced convulsions and lethality in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Drug Therapy, Combination; Excitatory Amino | 1999 |
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino | 2000 |
New non competitive AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsa | 2000 |
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 2001 |
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain Ischemia | 2001 |
beta-Adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Disease | 2001 |
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiet | 1991 |