gyki 52466 has been researched along with Drug Withdrawal Symptoms in 4 studies
GYKI 52466: an AMPA (non-NMDA) receptor antagonist; structure given in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| " The contribution of various excitatory amino acid (EAA) receptors (NMDA, AMPA/kainate and metabotropic) in the brain to the development of morphine dependence was examined." | 7.69 | Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence. ( Coderre, TJ; Fundytus, ME, 1994) |
| " The contribution of various excitatory amino acid (EAA) receptors (NMDA, AMPA/kainate and metabotropic) in the brain to the development of morphine dependence was examined." | 3.69 | Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence. ( Coderre, TJ; Fundytus, ME, 1994) |
| " Mice withdrawn from chronic treatment with diazepam showed a time-related evolution of anxiety, muscle rigidity, and seizures between days 4 and 21 after treatment discontinuation." | 3.68 | Diazepam dependence prevented by glutamate antagonists. ( Steppuhn, KG; Turski, L, 1993) |
| "Craving and relapse are core symptoms of drug addiction and alcoholism." | 1.33 | Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. ( Bachteler, D; Borchardt, T; Gass, P; Sanchis-Segura, C; Spanagel, R; Sprengel, R; Vengeliene, V; Zghoul, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanchis-Segura, C | 1 |
| Borchardt, T | 1 |
| Vengeliene, V | 1 |
| Zghoul, T | 1 |
| Bachteler, D | 1 |
| Gass, P | 1 |
| Sprengel, R | 1 |
| Spanagel, R | 1 |
| Xiang, K | 1 |
| Tietz, EI | 1 |
| Fundytus, ME | 1 |
| Coderre, TJ | 1 |
| Steppuhn, KG | 1 |
| Turski, L | 1 |
4 other studies available for gyki 52466 and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse.
Topics: Alcoholism; Animals; Benzodiazepines; Conditioning, Operant; Cues; Ethanol; Excitatory Amino Acid An | 2006 |
Benzodiazepine-induced hippocampal CA1 neuron alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid (AMPA) receptor plasticity linked to severity of withdrawal anxiety: differential role of voltage-gated calcium channels and N-methyl-D-aspartic acid re
Topics: Animals; Anxiety; Benzodiazepines; Calcium Channels, L-Type; Disease Models, Animal; Dizocilpine Mal | 2007 |
Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence.
Topics: Alanine; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzoates; Benzodiazepines; Dizocilpine Mal | 1994 |
Diazepam dependence prevented by glutamate antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Tolerance; Electroencephalography; Ele | 1993 |