gyki 52466 has been researched along with Disease Models, Animal in 25 studies
GYKI 52466: an AMPA (non-NMDA) receptor antagonist; structure given in first source
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA(A) receptors are progressively internalized with continued seizure activity." | 7.76 | Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466. ( Fritsch, B; Joelle Donofrio, J; Rogawski, MA; Stott, JJ, 2010) |
| "The GYKI 52466-pretreatment did not prevent the astrocyte swelling in the investigated cortical areas; thus we conclude that the AMPA-receptors have little if any involvement in the in the mediation of neuropathological alterations in acute convulsions." | 5.35 | Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. ( Krisztin-Péva, B; Mihály, A; Weiczner, R, 2008) |
| "Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA(A) receptors are progressively internalized with continued seizure activity." | 3.76 | Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466. ( Fritsch, B; Joelle Donofrio, J; Rogawski, MA; Stott, JJ, 2010) |
| "In this study, we evaluated whether beta-adrenoceptor antagonists may modify the protective efficacy of dizocilpine (MK-801), a NMDA receptor antagonist, and 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466), a non-NMDA (AMPA/kainate) receptor antagonist, against maximal electroshock-induced seizures in mice." | 3.71 | beta-Adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock. ( Kleinrok, Z; Luchowska, E; Luchowski, P; Urbanska, EM; Wielosz, M, 2001) |
| " GYKI 52466 was also protective against seizures and lethality induced by 4-aminopyridine, kainate and AMPA, but not by NMDA, whereas NBQX was ineffective in these chemoconvulsant tests." | 3.68 | Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. ( Donevan, SD; Rogawski, MA; Yamaguchi, S, 1993) |
| "Lentinan (LNT) is an immune regulator and its potential and mechanism for the treatment of mood disorder is of our interest." | 1.46 | Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway. ( Bao, H; Du, J; Du, K; Gao, T; Hou, Y; Hu, W; Li, B; Nie, J; Ran, P; Shan, L; Sun, L; Xiao, C; Zheng, B; Zheng, S; Zhu, K; Zhu, Y, 2017) |
| " The results show that a binge dosing regimen of METH to the rat increased plasma and brain ammonia concentrations that were paralleled by evidence of hepatotoxicity." | 1.38 | Peripheral ammonia as a mediator of methamphetamine neurotoxicity. ( Halpin, LE; Yamamoto, BK, 2012) |
| "The GYKI 52466-pretreatment did not prevent the astrocyte swelling in the investigated cortical areas; thus we conclude that the AMPA-receptors have little if any involvement in the in the mediation of neuropathological alterations in acute convulsions." | 1.35 | Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. ( Krisztin-Péva, B; Mihály, A; Weiczner, R, 2008) |
| " Both short- and long-term administration of lithium resulted in robust antidepressant-like effects in the mouse FST and TST." | 1.35 | Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test. ( Chen, G; Dow, ER; Du, J; Gould, TD; Manji, HK; O'Donnell, KC, 2008) |
| " We found that chronic administration of the antimanic agents lithium and valproate (VPA) reduced synaptic AMPA receptor GluR1/2 in hippocampal neurons in vitro and in vivo." | 1.35 | The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. ( Blumenthal, R; Chen, G; Creson, TK; Du, J; Falke, C; Gray, NA; Machado-Vieira, R; Manji, HK; Ren, M; Wang, Y; Wei, Y; Wu, LJ; Yuan, P; Zhuo, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gitto, R | 1 |
| Orlando, V | 1 |
| Quartarone, S | 1 |
| De Sarro, G | 1 |
| De Sarro, A | 1 |
| Russo, E | 1 |
| Ferreri, G | 1 |
| Chimirri, A | 1 |
| Malik, S | 1 |
| Bahare, RS | 1 |
| Khan, SA | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Nayak, PK | 2 |
| Kerr, DS | 2 |
| Li, B | 3 |
| Hou, Y | 3 |
| Zhu, M | 2 |
| Bao, H | 4 |
| Nie, J | 3 |
| Zhang, GY | 1 |
| Shan, L | 3 |
| Yao, Y | 1 |
| Du, K | 2 |
| Yang, H | 1 |
| Li, M | 1 |
| Zheng, B | 2 |
| Xu, X | 2 |
| Xiao, C | 4 |
| Du, J | 6 |
| Ran, P | 3 |
| Sun, L | 3 |
| Li, H | 2 |
| Zheng, S | 2 |
| Zhu, Y | 1 |
| Hu, W | 2 |
| Zhu, K | 2 |
| Gao, T | 1 |
| Fritsch, B | 1 |
| Stott, JJ | 1 |
| Joelle Donofrio, J | 1 |
| Rogawski, MA | 2 |
| Farley, S | 1 |
| Apazoglou, K | 1 |
| Witkin, JM | 1 |
| Giros, B | 1 |
| Tzavara, ET | 1 |
| Halpin, LE | 1 |
| Yamamoto, BK | 1 |
| Colak, A | 1 |
| Soy, O | 1 |
| Uzun, H | 1 |
| Aslan, O | 1 |
| Barut, S | 1 |
| Belce, A | 1 |
| Akyildiz, A | 1 |
| Taşyürekli, M | 1 |
| Suzuki, F | 1 |
| Heinrich, C | 1 |
| Boehrer, A | 1 |
| Mitsuya, K | 1 |
| Kurokawa, K | 1 |
| Matsuda, M | 1 |
| Depaulis, A | 1 |
| Eyüpoglu, IY | 1 |
| Hahnen, E | 1 |
| Heckel, A | 1 |
| Siebzehnrübl, FA | 1 |
| Buslei, R | 1 |
| Fahlbusch, R | 1 |
| Blümcke, I | 1 |
| Gressens, P | 1 |
| Spedding, M | 1 |
| Gigler, G | 1 |
| Kertesz, S | 1 |
| Villa, P | 1 |
| Medja, F | 1 |
| Williamson, T | 1 |
| Kapus, G | 2 |
| Levay, G | 1 |
| Szenasi, G | 1 |
| Barkoczy, J | 1 |
| Harsing, LG | 2 |
| Domínguez, MI | 1 |
| Blasco-Ibáñez, JM | 1 |
| Crespo, C | 1 |
| Nacher, J | 1 |
| Marqués-Marí, AI | 1 |
| Martínez-Guijarro, FJ | 1 |
| Xiang, K | 1 |
| Tietz, EI | 1 |
| Weiczner, R | 1 |
| Krisztin-Péva, B | 1 |
| Mihály, A | 1 |
| Gould, TD | 1 |
| O'Donnell, KC | 1 |
| Dow, ER | 1 |
| Chen, G | 2 |
| Manji, HK | 2 |
| Creson, TK | 1 |
| Wu, LJ | 1 |
| Ren, M | 1 |
| Gray, NA | 1 |
| Falke, C | 1 |
| Wei, Y | 1 |
| Wang, Y | 1 |
| Blumenthal, R | 1 |
| Machado-Vieira, R | 1 |
| Yuan, P | 1 |
| Zhuo, M | 1 |
| Yamaguchi, S | 1 |
| Donevan, SD | 1 |
| Abrahám, G | 1 |
| Sólyom, S | 1 |
| Csuzdi, E | 1 |
| Berzsenyi, P | 1 |
| Ling, I | 1 |
| Tarnawa, I | 1 |
| Hámori, T | 1 |
| Pallagi, I | 1 |
| Horváth, K | 1 |
| Andrási, F | 1 |
| Király, I | 1 |
| Patthy, M | 1 |
| Horváth, G | 1 |
| Luchowska, E | 1 |
| Luchowski, P | 1 |
| Wielosz, M | 1 |
| Kleinrok, Z | 1 |
| Urbanska, EM | 1 |
25 other studies available for gyki 52466 and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; | 2003 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, | 2013 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Functional preservation of hippocampal CA1 by low-dose GYKI-52466 preconditioning in a rat model of hypoxic-ischemic brain injury.
Topics: Animals; Benzodiazepines; CA1 Region, Hippocampal; Disease Models, Animal; Hypoxia-Ischemia, Brain; | 2015 |
3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway.
Topics: Animals; Antidepressive Agents; Benzodiazepines; Deoxyadenosines; Depressive Disorder; Disease Model | 2016 |
The Prefrontal Dectin-1/AMPA Receptor Signaling Pathway Mediates The Robust and Prolonged Antidepressant Effect of Proteo-β-Glucan from Maitake.
Topics: Animals; Antidepressive Agents; Benzodiazepines; beta-Glucans; Depression; Disease Models, Animal; G | 2016 |
Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway.
Topics: Adjuvants, Immunologic; Animals; Antidepressive Agents, Tricyclic; Benzodiazepines; Depression; Dise | 2017 |
Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepines; Depression; Disease Models, Anima | 2017 |
Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blood Pressure; Diazepam; Disease Model | 2010 |
Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepines; Chronic Disease; Depression; Depr | 2010 |
Peripheral ammonia as a mediator of methamphetamine neurotoxicity.
Topics: Alanine Transaminase; Ammonia; Analysis of Variance; Animals; Aspartate Aminotransferases; Benzodiaz | 2012 |
Low-dose GYKI-52466: prophylactic preconditioning confers long-term neuroprotection and functional recovery following hypoxic-ischaemic brain injury.
Topics: Animals; Benzodiazepines; Brain; Carotid Artery Diseases; Carotid Artery, Common; Disease Models, An | 2013 |
Neuroprotective effects of GYKI 52466 on experimental spinal cord injury in rats.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepines; Case-Co | 2003 |
Glutamate receptor antagonists and benzodiazepine inhibit the progression of granule cell dispersion in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Benzodiazepines; Cell Count; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Ep | 2005 |
Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note.
Topics: Animals; Benzodiazepines; Brain Neoplasms; Cell Death; Cell Movement; Cell Proliferation; Dentate Gy | 2005 |
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cell Survival; C | 2005 |
Neural overexcitation and implication of NMDA and AMPA receptors in a mouse model of temporal lobe epilepsy implying zinc chelation.
Topics: Animals; Benzodiazepines; Cell Death; Chelating Agents; Disease Models, Animal; Ditiocarb; Dizocilpi | 2006 |
Benzodiazepine-induced hippocampal CA1 neuron alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid (AMPA) receptor plasticity linked to severity of withdrawal anxiety: differential role of voltage-gated calcium channels and N-methyl-D-aspartic acid re
Topics: Animals; Anxiety; Benzodiazepines; Calcium Channels, L-Type; Disease Models, Animal; Dizocilpine Mal | 2007 |
Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Benzodiazepines; Brain | 2008 |
Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepines; Brain; Depression; Disease Models | 2008 |
The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior.
Topics: Animals; Antimanic Agents; Behavior, Animal; Benzodiazepines; Bipolar Disorder; Cells, Cultured; Dis | 2008 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Age | 1993 |
New non competitive AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsa | 2000 |
beta-Adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Disease | 2001 |