gyki 52466 has been researched along with Brain Ischemia in 11 studies
GYKI 52466: an AMPA (non-NMDA) receptor antagonist; structure given in first source
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The inhibition of seizure evoked by maximal electroshock was also found to be remarkable: the ED(50) values of GYKI 52466 and its two analogues were 6." | 1.31 | Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. ( Gacsályi, I; Gigler, G; Gyertyán, I; Lévay, G; Szabados, T, 2001) |
| "Treatment with GYKI 52466 or LY 231617 reduced the deficit in spatial learning by limiting the increase in swim distance due to ischemia." | 1.30 | Correlation between hippocampal neuronal damage and spatial learning deficit due to global ischemia. ( Block, F; Schwarz, M, 1997) |
| "Pretreatment with GYKI 52466 protected rats against behavioural deficits and hippocampal neuronal damage induced by 4VO." | 1.29 | Pretreatment but not posttreatment with GYKI 52466 reduces functional deficits and neuronal damage after global ischemia in rats. ( Block, F; Schmitt, W; Schwarz, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (63.64) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hámori, T | 1 |
| Sólyom, S | 1 |
| Berzsenyi, P | 1 |
| Andrási, F | 1 |
| Tarnawa, I | 1 |
| Caccamo, D | 1 |
| Campisi, A | 1 |
| Currò, M | 1 |
| Li Volti, G | 1 |
| Vanella, A | 1 |
| Ientile, R | 1 |
| Gressens, P | 1 |
| Spedding, M | 1 |
| Gigler, G | 3 |
| Kertesz, S | 1 |
| Villa, P | 1 |
| Medja, F | 1 |
| Williamson, T | 1 |
| Kapus, G | 1 |
| Levay, G | 3 |
| Szenasi, G | 1 |
| Barkoczy, J | 1 |
| Harsing, LG | 1 |
| Phillis, JW | 1 |
| Smith-Barbour, M | 1 |
| Perkins, LM | 1 |
| O'Regan, MH | 1 |
| Block, F | 2 |
| Schmitt, W | 1 |
| Schwarz, M | 2 |
| Arias, RL | 1 |
| Tasse, JR | 1 |
| Bowlby, MR | 1 |
| Chi, OZ | 1 |
| Chang, Q | 1 |
| Wang, G | 1 |
| Liu, X | 1 |
| Weiss, HR | 1 |
| Szabados, T | 2 |
| Gyertyán, I | 2 |
| Gacsályi, I | 2 |
| Smith, SE | 1 |
| Meldrum, BS | 1 |
1 review available for gyki 52466 and Brain Ischemia
| Article | Year |
|---|---|
Excitotoxic and post-ischemic neurodegeneration: Involvement of transglutaminases.
Topics: Animals; Benzodiazepines; Brain Ischemia; Calcium; Cells, Cultured; Dizocilpine Maleate; Excitatory | 2004 |
10 other studies available for gyki 52466 and Brain Ischemia
| Article | Year |
|---|---|
Structural analogues of some highly active non-competitive AMPA antagonists.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Behavior, Animal; Benzodiazepines; Brain Is | 2000 |
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cell Survival; C | 2005 |
GYKI 52466 and ischemia-evoked neurotransmitter amino acid release from rat cerebral cortex.
Topics: Amino Acids; Animals; Anti-Anxiety Agents; Benzodiazepines; Blood Gas Analysis; Blood Pressure; Brai | 1993 |
Pretreatment but not posttreatment with GYKI 52466 reduces functional deficits and neuronal damage after global ischemia in rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Damage, Chronic; Brain Ischemia; Corpus Striatu | 1996 |
Correlation between hippocampal neuronal damage and spatial learning deficit due to global ischemia.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Ischemia; Butylated Hydroxytoluene; Corpus Stri | 1997 |
Neuroprotective interaction effects of NMDA and AMPA receptor antagonists in an in vitro model of cerebral ischemia.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Ischemia; Dizocilpine Maleate; Excitatory Amino | 1999 |
A nonNMDA antagonist, GYKI 52466 improves microscopic O2 balance in the cortex during focal cerebral ischemia.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Brain Ischemia; Cerebral Cortex; Cere | 1999 |
Duration of action of GYKI 52466 and its analogues in antiepileptic, anti-ischaemic and muscle relaxant tests.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antag | 1999 |
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain Ischemia | 2001 |
Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Brain; Brain Ischemia; Infusions, Int | 1992 |