gyki 52466 and Brain Edema studies

GYKI 52466: an AMPA (non-NMDA) receptor antagonist; structure given in first source

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

Excerpt	Relevance	Reference
" In the present study the activity of bimoclomol was tested in experimental subarachnoid hemorrhage (SAH) and arachidonic acid (AA)-induced brain edema in rats to elucidate whether the compound may also have beneficial effect in cerebrovascular disturbances."	7.70	Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats. ( Erdö, F; Erdö, SL, 1998)
" In the present study the activity of bimoclomol was tested in experimental subarachnoid hemorrhage (SAH) and arachidonic acid (AA)-induced brain edema in rats to elucidate whether the compound may also have beneficial effect in cerebrovascular disturbances."	3.70	Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats. ( Erdö, F; Erdö, SL, 1998)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

gyki 52466 and Brain Edema

Research Excerpts

Research

Studies (1)

Authors

Other Studies