gyki 52466 has been researched along with Amyotrophic Lateral Sclerosis in 2 studies
GYKI 52466: an AMPA (non-NMDA) receptor antagonist; structure given in first source
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rothstein, JD | 1 |
| Bristol, LA | 1 |
| Hosler, B | 1 |
| Brown, RH | 1 |
| Kuncl, RW | 1 |
| Vartiainen, N | 1 |
| Tikka, T | 1 |
| Keinänen, R | 1 |
| Chan, PH | 1 |
| Koistinaho, J | 1 |
2 other studies available for gyki 52466 and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Anti-Anxiety Agents; Antio | 1994 |
Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyo | 1999 |