gw9662 and Liver-Diseases

gw9662 has been researched along with Liver-Diseases* in 1 studies

Other Studies

1 other study(ies) available for gw9662 and Liver-Diseases

ArticleYear
Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock.
    European journal of pharmacology, 2004, Feb-20, Volume: 486, Issue:2

    We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the anaesthetised rat. Thus, endogenous ligands for PPAR-gamma are released in haemorrhagic, but not endotoxic, shock in sufficient amounts to protect against injury.

    Topics: Anilides; Animals; Endotoxins; Escherichia coli; Ligands; Liver Diseases; Male; PPAR gamma; Rats; Rats, Wistar; Shock, Hemorrhagic; Shock, Septic

2004