gw-6471 and Sepsis

The heart is one of the most commonly affected organs during sepsis. Mitsugumin-53 (MG53) has attracted attention in research due to its cardioprotective function. However, the role of MG53 in sepsis-induced myocardial dysfunction (SIMD) remains unknown. The purpose of this study was to explore the underlying mechanism of MG53 in SIMD and investigate its potential relationship with peroxisome proliferator-activated receptor-. The cecal ligation and puncture (CLP) model was created to induce SIMD in rats. Protein levels of MG53 and PPAR. The expression of MG53 and PPAR. Both MG53 and PPAR

Topics: Animals; Apoptosis; Humans; Inflammation; Models, Biological; Muscle Proteins; Myocardium; Myocytes, Cardiac; Oxazoles; Oxidative Stress; PPAR alpha; Protective Agents; Rats, Sprague-Dawley; Sepsis; Survival Analysis; Tyrosine; Up-Regulation; Vesicular Transport Proteins