gw-501516 and Multiple-Sclerosis

gw-501516 has been researched along with Multiple-Sclerosis* in 1 studies

Other Studies

1 other study(ies) available for gw-501516 and Multiple-Sclerosis

Article	Year
Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation. Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1 We successfully synthesized a novel peroxisome proliferator-activated receptor (PPAR)δ selective agonist, namely, compound 20, with a characteristic benzisoxazole ring. Compound 20 exhibited potent human PPARδ transactivation activity and high δ selectivity. Further, it stimulated differentiation of primary oligodendrocyte precursor cells in vitro, indicating that it may be an effective drug in the treatment of demyelinating disorders such as multiple sclerosis. Topics: Animals; Brain; Cell Differentiation; Humans; Isoxazoles; Multiple Sclerosis; Oligodendroglia; Oxazoles; PPAR delta; Rats; Transcriptional Activation	2011

Article

Year

Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation.

Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

We successfully synthesized a novel peroxisome proliferator-activated receptor (PPAR)δ selective agonist, namely, compound 20, with a characteristic benzisoxazole ring. Compound 20 exhibited potent human PPARδ transactivation activity and high δ selectivity. Further, it stimulated differentiation of primary oligodendrocyte precursor cells in vitro, indicating that it may be an effective drug in the treatment of demyelinating disorders such as multiple sclerosis.

Topics: Animals; Brain; Cell Differentiation; Humans; Isoxazoles; Multiple Sclerosis; Oligodendroglia; Oxazoles; PPAR delta; Rats; Transcriptional Activation

2011