gw-4869 and Prostatic-Neoplasms

gw-4869 has been researched along with Prostatic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for gw-4869 and Prostatic-Neoplasms

ArticleYear
Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer.
    BMC immunology, 2022, 08-08, Volume: 23, Issue:1

    Tumor-associated macrophages are considered to be a major contributor affecting the development of tumors. Recently, numerous studies have shown that tumor cells were able to educate their microenvironment by delivering a significant amount of exosomes, however, the mechanism that exosomes from PCa cells work in macrophage polarization remains obscure. Therefore, we sought to determine whether blockade of exosome generation by GW4869, an inhibitor of exosome biogenesis, would impede macrophages from differentiating into M2 cells.. In this study, we first obtained exosomes from the supernatant media of PCa cells cultured with exosome-free serum using the Magcaptureâ„¢ Exosome Isolation Kit PS, and then investigated their effects on macrophages. Our data confirmed that exosomes released by prostate cancer cells can induce macrophages to differentiate into M2 cells. Mechanistically speaking, exosomes exert their effects on macrophages through activating the AKT and STAT3 signaling pathways. Importantly, treatment with GW4869 significantly inhibited the release of exosomes from PCa cells, and further impaired M2 differentiation of macrophages and their pro-tumor activity. We also demonstrated that GW4869 was able to inhibit the education of M2 macrophages, and then inhibit the progression of prostate cancer in vivo.. In brief, our findings indicated that GW4869 impeded the PCa exosome-induced M2 differentiation of macrophages and the progression of prostate cancer, suggesting that GW4869 could play an important role in the treatment of prostate cancer metastasis as an inhibitor of tumor exosome secretion.

    Topics: Aniline Compounds; Benzylidene Compounds; Exosomes; Humans; Macrophages; Male; Prostatic Neoplasms; Tumor Microenvironment

2022
Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells.
    Scientific reports, 2018, 03-01, Volume: 8, Issue:1

    Topics: Aniline Compounds; Benzylidene Compounds; Black or African American; Cell Line, Tumor; Cell Survival; Exosomes; Humans; Hypoxia; Male; Prognosis; Prostate; Prostatic Neoplasms; rab5 GTP-Binding Proteins; Signal Transduction; Tetraspanin 30; Tumor Microenvironment; United States; White People

2018