gw-4869 has been researched along with Colitis--Ulcerative* in 1 studies
1 other study(ies) available for gw-4869 and Colitis--Ulcerative
| Article | Year |
|---|---|
From Hair to Colon: Hair Follicle-Derived MSCs Alleviate Pyroptosis in DSS-Induced Ulcerative Colitis by Releasing Exosomes in a Paracrine Manner.
Ulcerative colitis (UC) has attracted intense attention due to its high recurrence rate and the difficulty of treatment. Pyroptosis has been suggested to be crucial in the development of UC. Although mesenchymal stem cells (MSCs) are broadly used for UC therapy, they have rarely been studied in the context of UC pyroptosis. Hair follicle-derived MSCs (HFMSCs) are especially understudied with regard to UC and pyroptosis. In this study, we aimed to discover the effects and potential mechanisms of HFMSCs in UC. We administered HFMSCs to dextran sulfate sodium- (DSS-) treated mice and found that the HFMSCs significantly inhibited pyroptosis to alleviate DSS-induced UC. A transwell system and GW4869, an exosome inhibitor, were used to prove the paracrine mechanism of HFMSCs. HFMSC supernatant reduced pyroptosis-related protein expression and promoted cell viability, but these effects were attenuated by GW4869, suggesting a role for HFMSC-released exosomes (Exos) in pyroptosis. Next, Exos were extracted and administered Topics: Aniline Compounds; Animals; Benzylidene Compounds; Colitis, Ulcerative; Dextran Sulfate; Exosomes; Hair Follicle; Interferons; Ligands; Mesenchymal Stem Cells; Mice; MicroRNAs; Pyroptosis; Tissue Distribution; Tumor Necrosis Factors | 2022 |