gw-4869 and Aortic-Diseases

gw-4869 has been researched along with Aortic-Diseases* in 1 studies

Other Studies

1 other study(ies) available for gw-4869 and Aortic-Diseases

Article	Year
nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe Arteriosclerosis, thrombosis, and vascular biology, 2018, Volume: 38, Issue:7 Atherosclerosis is a chronic multifactorial and inflammatory disease of large and medium arteries and the leading cause of cardiovascular diseases worldwide. The aim of this study was to investigate whether and how the nSMase2 (type 2-neutral sphingomyelinase), a key enzyme of sphingolipid metabolism, may contribute to the development of atherosclerotic lesions.. The role of nSMase2 in atherosclerosis was investigated in. The genetic deficiency or inhibition of nSMase2 strongly decreases the development of atherosclerotic lesions in Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Aorta; Aortic Diseases; Atherosclerosis; Benzylidene Compounds; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Inflammation; Inflammation Mediators; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; NF-E2-Related Factor 2; Plaque, Atherosclerotic; RAW 264.7 Cells; Signal Transduction; Sphingomyelin Phosphodiesterase	2018

Article

Year

nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe

Arteriosclerosis, thrombosis, and vascular biology, 2018, Volume: 38, Issue:7

Atherosclerosis is a chronic multifactorial and inflammatory disease of large and medium arteries and the leading cause of cardiovascular diseases worldwide. The aim of this study was to investigate whether and how the nSMase2 (type 2-neutral sphingomyelinase), a key enzyme of sphingolipid metabolism, may contribute to the development of atherosclerotic lesions.. The role of nSMase2 in atherosclerosis was investigated in. The genetic deficiency or inhibition of nSMase2 strongly decreases the development of atherosclerotic lesions in

Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Aorta; Aortic Diseases; Atherosclerosis; Benzylidene Compounds; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Inflammation; Inflammation Mediators; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; NF-E2-Related Factor 2; Plaque, Atherosclerotic; RAW 264.7 Cells; Signal Transduction; Sphingomyelin Phosphodiesterase

2018