gw-4064 and Weight-Gain

gw-4064 has been researched along with Weight-Gain* in 1 studies

Other Studies

1 other study(ies) available for gw-4064 and Weight-Gain

Article	Year
Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorganic & medicinal chemistry letters, 2011, Feb-15, Volume: 21, Issue:4 To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1c lowered body weight gain and serum glucose in a DIO mouse model of diabetes. Topics: Animals; Binding Sites; Blood Glucose; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Dogs; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Mice; Molecular Conformation; Naphthalenes; Protein Structure, Tertiary; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Weight Gain	2011

Article

Year

Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.

Bioorganic & medicinal chemistry letters, 2011, Feb-15, Volume: 21, Issue:4

To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1c lowered body weight gain and serum glucose in a DIO mouse model of diabetes.

Topics: Animals; Binding Sites; Blood Glucose; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Dogs; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Mice; Molecular Conformation; Naphthalenes; Protein Structure, Tertiary; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Weight Gain

2011