gw-3965 has been researched along with Pericarditis* in 1 studies
1 other study(ies) available for gw-3965 and Pericarditis
| Article | Year |
|---|---|
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
Reported as two antirenal cell carcinoma (RCC) drug candidates, marine-derived compounds piericidin A (PA) and glucopiericidin A (GPA) exhibit hepatotoxicity in renal carcinoma xenograft mice. Proteomics and transcriptomics reveal the hepatotoxicity related with cholesterol disposition since RCC is characterized by cholesterol accumulation. PA/GPA aggravate hepatotoxicity in high-cholesterol diet (HCD)-fed mice while exhibiting no toxicity in chow diet-fed mice. High cholesterol accumulation in liver is liver X receptor (LXR)-mediated cytochrome P450 family 7 subfamily a member 1 (CYP7A1) depression and low-density lipoprotein receptor (LDLR) activation. The farnesoid X nuclear receptor (FXR) is also depressed with a downregulated target gene Topics: Animals; Cholesterol; Cholesterol, Dietary; Diet, High-Fat; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Pericarditis; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |