gw-3965 and Cerebral-Infarction

Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, including neuroinflammation. However, the ability of LXR agonists to suppress stroke-associated inflammation has not been evaluated. Here, we have used time-lapse magnetic resonance imaging (MRI) to show that a single dose of an LXR ligand administered post-injury dramatically reduces brain damage in a model of acute brain ischemia. Neuroprotection was associated with suppression of neuroinflammation.

Topics: Animals; Benzoates; Benzylamines; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; DNA-Binding Proteins; Ligands; Liver X Receptors; Magnetic Resonance Imaging; Male; Orphan Nuclear Receptors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear