gw-2580 and Brain-Ischemia

Microglia are primary immune cells within the brain and are rapidly activated after cerebral ischemia. The degree of microglial activation is closely associated with the severity of ischemia. However, it remains largely unclear how microglial activation is differentially regulated in response to a different degree of ischemia. In this study, we used a bilateral common carotid artery ligation (BCAL) model and induced different degrees of ischemia by varying the duration of ligation to investigate the microglial response in CX3CR1

Topics: Animals; Anisoles; Brain Ischemia; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Green Fluorescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrimidines; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Severity of Illness Index; Signal Transduction; Transcriptome; Up-Regulation