guanylyl-imidodiphosphate and Creutzfeldt-Jakob-Syndrome
guanylyl-imidodiphosphate has been researched along with Creutzfeldt-Jakob-Syndrome* in 1 studies
Other Studies
1 other study(ies) available for guanylyl-imidodiphosphate and Creutzfeldt-Jakob-Syndrome
Article | Year |
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Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain.
Creutzfeldt-Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt-Jakob disease show increased guanyl nucleotide- or 5-hydroxytryptamine-mediated activation of adenylate cyclase. This increased enzyme activity appears due, primarily, to facilitated 'coupling' between the GTP-binding protein which stimulates adenylate cyclase (GNs) and the catalytic moiety of that enzyme rather than increased sensitivity to 5-hydroxytryptamine. It is possible that this phenomenon is due to direct effects of the Creutzfeldt-Jakob infectious agent, or a pathological product resulting from that agent, upon synaptic membrane adenylate cyclase. Topics: Adenylyl Cyclases; Animals; Brain; Creutzfeldt-Jakob Syndrome; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Guinea Pigs; Oncogene Proteins, Viral; Scrapie; Serotonin; Sodium Fluoride | 1986 |