guanylthiourea has been researched along with Malaria* in 1 studies
1 other study(ies) available for guanylthiourea and Malaria
| Article | Year |
|---|---|
Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies.
Guanylthiourea (GTU) derivatives were identified as possible anti-malarial agents, recently, using in vitro studies on Plasmodium falciparum. This article gives an account of the in vivo anti-malarial activity of GTU derivatives against experimental rodent malaria. A total of 20 synthesized GTU derivatives were evaluated for in vivo antimalarial activity, out of which six showed encouraging results; one compound appeared to have curative potential. Molecular docking and molecular dynamics analysis were carried out to understand the molecular level interactions. Topics: Antimalarials; Dose-Response Relationship, Drug; Guanylthiourea; Malaria; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship | 2017 |