guanylthiourea and Hypoxia

Pronounced antihypoxic and antioxidant effects of preventive injection of succinic acid, aminothiol antihypoxants gutimine and amtizol, and succinate-containing aminothiol antihypoxants gutimine succinate and amtizol succinate to Wistar rats with acute hypoxic hypoxia have been demonstrated. Exogenous succinic acid was inferior to aminothiol compounds by antihypoxic effect, but superior to them by its effect on the level of LPO products. Succinate in the aminothiol molecule modulated the intensity of their antihypoxic and antioxidant effects. It did not modulate the antihypoxic activity of amtizol, but reduced the antihypoxic effect of gutimine, presumably because of the physicochemical characteristics of aminothiols. Comparison of the intensities of antihypoxic and antioxidant effects of the studied drugs showed no direct relationship between these effects.

Topics: Animals; Antioxidants; Guanylthiourea; Hypoxia; Lipid Peroxidation; Male; Rats; Rats, Wistar; Succinic Acid; Thiadiazoles

Topics: Animals; Cats; Guanylthiourea; Hypoxia; In Vitro Techniques; Ion Channels; Leeches; Lymnaea; Neurons; Oxidation-Reduction; Visual Cortex

A study was made of the effects of isothiobarbamine and guthimine (10 and 50 mg/kg, respectively) on the content of cAMP and cGMP in the brain cortex (BC) and hippocamp under normal conditions and hypoxia. Isothiobarbamine did not change the content of both cyclic nucleotides under normoxia, whereas under hypoxia it reduced the level of the cyclic nucleotides in the BC and raised it in the hippocamp. Guthimine increased their content in the BC and did not change it in the hippocamp under normoxia, whereas under hypoxia it increased the cAMP content in the hippocamp and did not change it in the BC. The cGMP content descended in both the structures under study.

Topics: Animals; Brain; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Drug Evaluation, Preclinical; Guanylthiourea; Hippocampus; Hypoxia; Male; Rats; Rats, Inbred Strains; Thiopental; Thiourea

Topics: Acute Disease; Adolescent; Antidotes; Critical Care; Female; Guanylthiourea; Humans; Hypoxia; Insecticides; Malathion; Male; Middle Aged; Thiourea; Trichlorfon