guanosine-triphosphate and Nerve-Degeneration

guanosine-triphosphate has been researched along with Nerve-Degeneration* in 2 studies

Reviews

1 review(s) available for guanosine-triphosphate and Nerve-Degeneration

Article	Year
Cellular abnormalities in the brain in chronic liver disease. The Scientific basis of medicine annual reviews, 1972 Topics: Adenosine Triphosphate; Brain; Brain Chemistry; Brain Diseases; Cell Nucleolus; Cell Nucleus; Chronic Disease; DNA; Guanosine Triphosphate; Humans; Liver Diseases; Microscopy, Electron; Mitosis; Nerve Degeneration; Neuroglia; Portacaval Shunt, Surgical	1972

Other Studies

1 other study(ies) available for guanosine-triphosphate and Nerve-Degeneration

Article	Year
'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell death and differentiation, 2002, Volume: 9, Issue:9 By crossing Huntington's disease (HD) R6/1 transgenic mice with 'tissue' transglutaminase (TG2) knock-out mice, we have demonstrated that this multifunctional enzyme plays an important role in the neuronal death characterising this disorder in vivo. In fact, a large reduction in cell death is observed in R6/1, TG2(-/-) compared with R6/1 transgenic mice. In addition, we have shown that the formation of neuronal intranuclear inclusions (NII) is potentiated in absence of the 'tissue' transglutaminase. These phenomena are paralleled by a significant improvement both in motor performances and survival of R6/1, TG2(-/-) versus R6/1 mice. Taken together these findings suggest an important role for tissue transglutaminase in the regulation of neuronal cell death occurring in Huntington's disease. Topics: Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Female; GTP-Binding Proteins; Guanosine Triphosphate; Huntington Disease; Immunohistochemistry; Inclusion Bodies; Longevity; Male; Mice; Mice, Knockout; Microscopy, Electron; Motor Activity; Neocortex; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Protein Glutamine gamma Glutamyltransferase 2; Survival Rate; Transglutaminases	2002

Article

Year

'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease.

Cell death and differentiation, 2002, Volume: 9, Issue:9

By crossing Huntington's disease (HD) R6/1 transgenic mice with 'tissue' transglutaminase (TG2) knock-out mice, we have demonstrated that this multifunctional enzyme plays an important role in the neuronal death characterising this disorder in vivo. In fact, a large reduction in cell death is observed in R6/1, TG2(-/-) compared with R6/1 transgenic mice. In addition, we have shown that the formation of neuronal intranuclear inclusions (NII) is potentiated in absence of the 'tissue' transglutaminase. These phenomena are paralleled by a significant improvement both in motor performances and survival of R6/1, TG2(-/-) versus R6/1 mice. Taken together these findings suggest an important role for tissue transglutaminase in the regulation of neuronal cell death occurring in Huntington's disease.

Topics: Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Female; GTP-Binding Proteins; Guanosine Triphosphate; Huntington Disease; Immunohistochemistry; Inclusion Bodies; Longevity; Male; Mice; Mice, Knockout; Microscopy, Electron; Motor Activity; Neocortex; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Protein Glutamine gamma Glutamyltransferase 2; Survival Rate; Transglutaminases

2002