guanosine-triphosphate has been researched along with Hepatitis--Animal* in 1 studies
1 other study(ies) available for guanosine-triphosphate and Hepatitis--Animal
Article | Year |
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Rat liver eicosanoid synthesis during turpentine-induced inflammation.
Subcellular liver fractions from rats receiving a subcutaneous injection of turpentine, which causes a local inflammation, show an increased synthesis of Prostaglandin E2 and Prostaglandin F2 alpha which reaches a peak 90 minutes and 3 hours after treatment, respectively. Stimulation of phospholipase A2 activity of liver cell preparations seems to be responsible for the supply of arachidonic acid necessary to feed PG synthesis: this stimulation is accompanied by unchanged levels of diacylglycerol lipase, diacylglycerol kinase and protein kinase C activities and by an unchanged content of diacylglycerol in the liver tissue. This picture does not favour the hypothesis of an involvement of phospholipase C in the early stages after turpentine treatment. Determinations of GTP-ase activity in plasma membrane-rich liver preparations give ambiguous results, which do not allow any conclusion on the possible role of G-proteins in phospholipase A2 activation. Topics: Animals; Diglycerides; Dinoprost; Dinoprostone; Guanosine Triphosphate; Hepatitis, Animal; Male; Microsomes, Liver; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Inbred Strains; Subcellular Fractions; Turpentine | 1991 |