guanosine-triphosphate has been researched along with Granuloma* in 2 studies
2 other study(ies) available for guanosine-triphosphate and Granuloma
| Article | Year |
|---|---|
Investigations of anti-inflammatory activity of Jigrine.
Jigrine, a polypharmaceutical herbal formulation containing 14 medicinal plants is used in the Unani system of medicine for the treatment of liver ailments. The antiinflammatory activity of Jigrine (0.5 ml and 1.0 ml/kg, po), was evaluated against acute inflammation caused by carrageenin (injecting 0.1 ml of 1% carrageenin in 0.9% NaCl solution into plantar surface of the hind paw of the rat) and the effect of Jigrine (1 ml/kg/day, po for 7 days) was also studied on the sub-acute inflammation induced by cotton pellet granuloma. The paw volume, biochemical parameters like tissue AST, ALT, gamma-GTP and lipid peroxides and dry wt. of granuloma were measured to assess the anti-inflammatory activity. It showed a significant anti-inflammatory activity as evidenced by lowering the elevated levels of paw volume and biochemical parameters. But it could not reduce the sub-acute inflammation caused by cotton pellet granuloma. The study suggests that Jigrine has significant effect only on acute phase of inflammation caused by carrageenin. Antioxidant and membrane stabilizing action of Jigrine might be responsible for its anti-inflammatory effect. Topics: Alanine Transaminase; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carrageenan; Disease Models, Animal; Edema; Granuloma; Guanosine Triphosphate; Hindlimb; India; Lipid Peroxidation; Male; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar | 1997 |
Different responses to some stimulators of prolyl hydroxylase activities in various rat organs.
Prolyl hydroxylase (proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) of soluble fraction (105 000 X g supernatant) of rat granulation tissues was markedly enhanced by addition of nucleoside triphosphates to the assay medium. But the stimulatory activities of nucleoside triphosphates were very different in fractions derived from tissues of rat. In skin, lung or whole fetal tissues other than granuloma, GTP enhanced the enzymatic activity by 3-4 fold. On the other hand, in kidney, liver and spleen tissues it brought about no enhancement. The same results were obtained even if ATP regenerating system was added in the assay medium. The stimulatory effect of nucleoside triphosphates was not seen with the soluble fraction of liver, but it appeared with the enzyme fraction purified by affinity column chromatography. The same phenomenon was observed by addition of bovine serum albumin instead of nucleoside triphosphates as stimulator. We discuss the possible reasons as to why the responses of the enzyme to stimulators were quite different among various tissues. Topics: Adenosine Triphosphate; Animals; Brain; Carrageenan; Dose-Response Relationship, Drug; Enzyme Activation; Granuloma; Guanosine Triphosphate; Kidney; Liver; Lung; Myocardium; Procollagen-Proline Dioxygenase; Rats; Serum Albumin, Bovine; Spleen | 1977 |