guanosine-triphosphate and Endocrine-System-Diseases

The characterisation of receptor sites of hormones to various tissues in vivo and in vitro have introduced new insights for the evaluation of pathogenic mechanisms involved in endocrine and metabolic human diseases. Disorders at the receptor level are characterized by changes in the number of receptor sites, the affinity of the hormone to its specific receptors or by generation of anti-receptor antibodies, which impair hormone binding procedures or post-receptor metabolism. Altered receptor physiology may be of an important value as well for diagnosis and treatment of endocrine, metabolic and neoplastic diseases as for the understanding of their pathogenetic mechanisms.

Topics: Acanthosis Nigricans; Adenosine Triphosphate; Adenylyl Cyclases; Antibodies; Binding, Competitive; Cyclic AMP; Diabetes Complications; Endocrine System Diseases; Enzyme Activation; Graves Disease; Guanosine Triphosphate; Humans; Hypercholesterolemia; Insulin; Insulin Resistance; Lipoproteins, LDL; Metabolic Diseases; Myasthenia Gravis; Obesity; Receptors, Androgen; Receptors, Cell Surface; Receptors, Neurotransmitter

The characterization of binding parameters of hormones and drugs to specific receptors at various human cell types have introduced an interesting approach for the evaluation of pathogenic mechanisms involved in endocrine and metabolic disorders. The dysregulation of cellular receptors in those disease include changes in receptor number, changes in binding affinity and production of antibodies against receptor molecules. It can be concluded from these observations that altered receptor physiology may be of important value for abnormalities in cellular recognition and control mechanisms which can be observed in neoplastic, inflammatory, immune and developmental diseases.

Topics: Adenylyl Cyclases; Autoantibodies; Cyclic AMP; Endocrine System Diseases; Enzyme Activation; Guanosine Triphosphate; Hormones; Humans; Kinetics; Receptors, Cell Surface; Receptors, Cyclic AMP