guanosine-triphosphate and Dystonic-Disorders

GTP-cyclohydrolase deficiency in dopa-responsive dystonia (DRD) patients impairs the biosynthesis of dopamine, but also of serotonin. The high prevalence of non-motor symptoms suggests involvement of the serotonergic pathway. Our study aimed to investigate the serotonergic system in vivo in the brain of`DRD patients and correlate this to (non-)motor symptoms. Dynamic [

Topics: Dystonic Disorders; GTP Cyclohydrolase; Guanosine Triphosphate; Humans; Levodopa; Positron-Emission Tomography