guanosine-tetraphosphate and Neoplasms

In all organisms, DNA and protein are synthesized by dedicated, but unrelated, machineries that move along distinct templates with no apparent coordination. Therefore, connections between DNA replication and translation are a priori unexpected. However, recent findings support the existence of such connections throughout the three domains of life. In particular, we recently identified in archaeal genomes a conserved association between genes encoding DNA replication and ribosome-related proteins which all have eukaryotic homologs. We believe that this gene organization is biologically relevant and, moreover, that it suggests the existence of a mechanism coupling DNA replication and translation in Archaea and Eukarya.

Topics: Animals; Archaea; Bacteria; Bacterial Proteins; DNA Replication; Gene Order; Genome, Archaeal; Genome, Bacterial; Genome, Human; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Pentaphosphate; Guanosine Tetraphosphate; Humans; Multigene Family; Neoplasms; Protein Biosynthesis