guanosine-pentaphosphate and Typhoid-Fever

How Salmonella enterica serovar Typhi (S. Typhi), an important human pathogen, survives the stressful microenvironments inside the gastrointestinal tract and within macrophages remains poorly understood. We report here that S. Typhi has a bonafide stringent response (SR) system, which is mediated by (p)ppGpp and regulates multiple virulence-associated traits and the pathogenicity of the S. Typhi Ty2 strain. In an iron overload mouse model of S. Typhi infection, the (p)ppGpp

Topics: Animals; Bacterial Proteins; Caco-2 Cells; Disease Models, Animal; Gene Expression Regulation, Bacterial; GTP Pyrophosphokinase; Guanosine Pentaphosphate; Host-Pathogen Interactions; HT29 Cells; Humans; Iron Overload; Liver; Mice; Mice, Inbred BALB C; Mice, Knockout; Polysaccharides, Bacterial; Pyrophosphatases; RAW 264.7 Cells; Salmonella typhi; Signal Transduction; Spleen; Survival Analysis; THP-1 Cells; Typhoid Fever; Virulence