guanosine-monophosphate has been researched along with Pancreatitis* in 1 studies
1 other study(ies) available for guanosine-monophosphate and Pancreatitis
| Article | Year |
|---|---|
The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression.
Hyperglycemia-induced myelopoiesis and atherosclerotic progression occur in mice with type I diabetes. However, less is known about the effects of metabolites on myelopoesis in type 2 diabetes. Here, we use fluorescence-activated cell sorting to analyze the proliferation of granulocyte/monocyte progenitors (GMP) in db/db mice. Using targeted metabolomics, we identify an increase in inosine monophosphate (IMP) in GMP cells of 24-week-old mice. We show that IMP treatment stimulates cKit expression, ribosomal S6 activation, GMP proliferation, and Gr-1 Topics: Acute Disease; Animals; Diabetes Mellitus, Type 2; Guanosine Monophosphate; Inosine Monophosphate; Mice; Myelopoiesis; Pancreatitis; Purines | 2022 |