guanosine-monophosphate has been researched along with Heart-Diseases* in 1 studies
1 review(s) available for guanosine-monophosphate and Heart-Diseases
Article | Year |
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Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.
Cyclic guanosine monophosphate (cGMP) is an important intracellular second messenger that mediates multiple tissue and cellular responses. The cGMP pathway is a key element in the pathophysiology of the heart and its modulation by drugs such as phosphodiesterase (PDE)-5 inhibitors and guanylate cyclase activators may represent a promising therapeutic approach for acute myocardial infarction, cardiac hypertrophy, heart failure, and doxorubicin cardiotoxicity in patients. In addition, PDE-5 inhibitors may prove to be innovative therapeutic agents for enhancing the chemosensitivity of doxorubicin while providing concurrent cardiac benefit. Topics: Animals; Guanosine Monophosphate; Heart Diseases; Humans; Myocytes, Cardiac; Phosphodiesterase 5 Inhibitors; Signal Transduction | 2012 |