guanosine-monophosphate and Carbon-Monoxide-Poisoning

Carbon monoxide (CO) is much more than just a toxic gas. Carbon monoxide is produced endogenously by the enzyme heme oxygenase and has important functions under physiological and pathophysiological conditions. Recent studies suggested antioxidative, anti-inflammatory, antiproliferative, anti-apoptotic, and vasodilating characteristics. Regarding clinically-relevant diseases in anesthesiology and critical care medicine, such as adult respiratory distress syndrome (ARDS), sepsis, or during organ transplantation, cytoprotective properties have been demonstrated by low-dose CO in experimental models. In view of a potential CO application in future human studies, this review discusses what is known to date about CO as it relates to functional, protective and toxic aspects.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Atherosclerosis; Carbon Monoxide; Carbon Monoxide Poisoning; Fibrinolytic Agents; Guanosine Monophosphate; Heme Oxygenase (Decyclizing); Humans; Mitogen-Activated Protein Kinases; Sepsis