guanosine-monophosphate and Arteriosclerosis

guanosine-monophosphate has been researched along with Arteriosclerosis* in 2 studies

Other Studies

2 other study(ies) available for guanosine-monophosphate and Arteriosclerosis

Article	Year
Studies with guanosine-5'-monophosphate (GMP): new method for measurement and effects on blood pressure. Clinical and experimental hypertension. Part A, Theory and practice, 1992, Volume: 14, Issue:4 A practical new method for measuring serum guanosine-5'-monophosphate (GMP) was developed and three experiments were performed using this method. In the first, we observed the reduction of blood pressure (BP) and the elevation of serum GMP level persisting for 3 hours in male Japanese White Rabbits administered GMP, 50 mg/kg given as a single oral dose. In the second, 6-week-old male spontaneously hypertensive rats (SHR) received GMP, 200 mg/kg/day, orally for 8 weeks. The systolic BP in the GMP-treated rats, which averaged 170.2 mmHg, was lower than that of the control group, which averaged 188.0 mmHg. Arteriosclerotic findings were milder in the GMP-treated SHR as compared to the control. In the third experiment, the serum GMP level was measured in humans. We observed a significant negative correlation between the serum GMP concentration and systolic or diastolic BP. In conclusion, GMP reduced the BP in experimental animals, suggesting that it may be useful as an antihypertensive agent. Topics: Administration, Oral; Aged; Animals; Antihypertensive Agents; Arteriosclerosis; Blood Chemical Analysis; Blood Pressure; Female; Guanosine Monophosphate; Humans; Hypertension; Male; Middle Aged; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY	1992
Cyclic AMP and cyclic GMP content in a short-term organ culture of normal and atherosclerotic human aorta. Artery, 1986, Volume: 13, Issue:6 Cyclic AMP and cyclic GMP content was measured in intima and media of unaffected and atherosclerotic areas of human aorta in a short-term organ culture. It was demonstrated that during short-term cultivation the content of both cyclic nucleotides in tissues is constant. The cyclic AMP content in fatty streaks and atherosclerotic plaques is significantly (2 to 7-fold) lower than in unaffected intima. The cyclic GMP level in atherosclerotic lesions is 1.5 to 3-fold higher than in normal. The content of both cyclic nucleotides in the media underlying fatty streaks is the same as in the normal tissue. In the media underlying atherosclerotic plaques, the cyclic AMP level is decreased compared to the normal. The obtained data indicates serious disorders in the system of cyclic nucleotides during atherosclerosis. Possible consequences of this disfunction are discussed. Topics: Aorta; Arteriosclerosis; Culture Techniques; Cyclic AMP; Guanine Nucleotides; Guanosine Monophosphate; Humans; Male	1986

Article

Year

Studies with guanosine-5'-monophosphate (GMP): new method for measurement and effects on blood pressure.

Clinical and experimental hypertension. Part A, Theory and practice, 1992, Volume: 14, Issue:4

A practical new method for measuring serum guanosine-5'-monophosphate (GMP) was developed and three experiments were performed using this method. In the first, we observed the reduction of blood pressure (BP) and the elevation of serum GMP level persisting for 3 hours in male Japanese White Rabbits administered GMP, 50 mg/kg given as a single oral dose. In the second, 6-week-old male spontaneously hypertensive rats (SHR) received GMP, 200 mg/kg/day, orally for 8 weeks. The systolic BP in the GMP-treated rats, which averaged 170.2 mmHg, was lower than that of the control group, which averaged 188.0 mmHg. Arteriosclerotic findings were milder in the GMP-treated SHR as compared to the control. In the third experiment, the serum GMP level was measured in humans. We observed a significant negative correlation between the serum GMP concentration and systolic or diastolic BP. In conclusion, GMP reduced the BP in experimental animals, suggesting that it may be useful as an antihypertensive agent.

Topics: Administration, Oral; Aged; Animals; Antihypertensive Agents; Arteriosclerosis; Blood Chemical Analysis; Blood Pressure; Female; Guanosine Monophosphate; Humans; Hypertension; Male; Middle Aged; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY

1992

Cyclic AMP and cyclic GMP content in a short-term organ culture of normal and atherosclerotic human aorta.

Artery, 1986, Volume: 13, Issue:6

Cyclic AMP and cyclic GMP content was measured in intima and media of unaffected and atherosclerotic areas of human aorta in a short-term organ culture. It was demonstrated that during short-term cultivation the content of both cyclic nucleotides in tissues is constant. The cyclic AMP content in fatty streaks and atherosclerotic plaques is significantly (2 to 7-fold) lower than in unaffected intima. The cyclic GMP level in atherosclerotic lesions is 1.5 to 3-fold higher than in normal. The content of both cyclic nucleotides in the media underlying fatty streaks is the same as in the normal tissue. In the media underlying atherosclerotic plaques, the cyclic AMP level is decreased compared to the normal. The obtained data indicates serious disorders in the system of cyclic nucleotides during atherosclerosis. Possible consequences of this disfunction are discussed.

Topics: Aorta; Arteriosclerosis; Culture Techniques; Cyclic AMP; Guanine Nucleotides; Guanosine Monophosphate; Humans; Male

1986