guanosine-5--o-(2-thiodiphosphate) has been researched along with Carcinoma--Squamous-Cell* in 2 studies
2 other study(ies) available for guanosine-5--o-(2-thiodiphosphate) and Carcinoma--Squamous-Cell
| Article | Year |
|---|---|
G protein activation of a hormone-stimulated phosphatase in human tumor cells.
The growth-inhibiting peptide hormone somatostatin stimulates phosphotyrosine phosphatase activity in the human pancreatic cell line MIA PaCa-2. This hormonal activation was mediated by a pertussis toxin-sensitive guanosine 5'-triphosphate-binding protein (G protein) in the membranes of these cells. Activation of this G protein by somatostatin stimulated the dephosphorylation of exogenous epidermal growth factor receptor prepared from A-431 cells in vitro. This pathway may mediate the antineoplastic action of somatostatin in these cells and in human tumors and could represent a general mechanism of G protein coupling that is utilized by normal cells in the hormonal control of cell growth. Topics: Adenosine Triphosphate; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Pancreatic Neoplasms; Peptides; Pertussis Toxin; Phosphorylation; Protein Kinases; Protein Tyrosine Phosphatases; Somatostatin; Thionucleotides; Virulence Factors, Bordetella | 1992 |
Growth factor-induced release of a glycosylphosphatidylinositol (GPI-) linked protein from HEp-2 carcinoma cells and human syncytiotrophoblast.
Topics: Alkaline Phosphatase; Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; Female; Giant Cells; Glycolipids; Glycosylphosphatidylinositols; Growth Substances; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Insulin; Isoenzymes; Kinetics; Phosphatidylinositols; Placenta; Pregnancy; Thionucleotides; Trophoblasts | 1991 |