guanidine has been researched along with Sensitivity and Specificity in 44 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (27.27) | 18.2507 |
| 2000's | 26 (59.09) | 29.6817 |
| 2010's | 6 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johansen, ML | 1 |
| Gao, Y | 1 |
| Hutnick, MA | 1 |
| Craig, SEL | 1 |
| Pokorski, JK | 1 |
| Flask, CA | 1 |
| Brady-Kalnay, SM | 1 |
| Gadermaier, E | 1 |
| Tesarz, M | 1 |
| Wallwitz, J | 1 |
| Berg, G | 1 |
| Himmler, G | 1 |
| Yang, W | 1 |
| Kernstock, R | 1 |
| Simmons, N | 1 |
| Alak, A | 1 |
| Biswas, G | 1 |
| Jeon, OY | 1 |
| Lee, WS | 1 |
| Kim, DC | 1 |
| Kim, KT | 1 |
| Lee, S | 1 |
| Chang, S | 1 |
| Chung, SK | 1 |
| Kumar, M | 1 |
| Sharma, S | 1 |
| Ram, AB | 1 |
| Khan, IA | 1 |
| Sarazin, C | 1 |
| Delaunay, N | 1 |
| Costanza, C | 1 |
| Eudes, V | 1 |
| Gareil, P | 1 |
| Noguchi, T | 1 |
| Shiraki, T | 1 |
| Dawn, A | 1 |
| Tsuchiya, Y | 1 |
| Lien, le TN | 1 |
| Yamamoto, T | 1 |
| Shinkai, S | 1 |
| Anslyn, EV | 1 |
| Shear, JB | 1 |
| Regimbal, RL | 1 |
| DePaula, CA | 1 |
| Guzelsu, N | 1 |
| Clay, O | 1 |
| Douady, CJ | 1 |
| Carels, N | 1 |
| Hughes, S | 1 |
| Bucciarelli, G | 1 |
| Bernardi, G | 1 |
| Leitner, A | 1 |
| Lindner, W | 1 |
| Luo, D | 1 |
| Lan, J | 1 |
| Zhou, C | 2 |
| Luo, C | 1 |
| Fuertes, MA | 1 |
| Pérez, JM | 1 |
| Alonso, C | 1 |
| Pantos, A | 1 |
| Tsiourvas, D | 1 |
| Sideratou, Z | 1 |
| Paleos, CM | 1 |
| Giatrellis, S | 1 |
| Nounesis, G | 1 |
| Campbell, R | 1 |
| Winkler, MA | 1 |
| Wu, H | 1 |
| Ganjali, MR | 1 |
| Rahimi, M | 1 |
| Maddah, B | 1 |
| Moghimi, A | 1 |
| Borhany, S | 1 |
| Qiu, J | 1 |
| Lee, H | 1 |
| Lin, X | 1 |
| Xu, DS | 1 |
| Feng, Y | 1 |
| Shen, L | 1 |
| Marti, DN | 1 |
| Clément-Collin, V | 1 |
| Barbier, A | 1 |
| Dergunov, AD | 1 |
| Visvikis, A | 1 |
| Siest, G | 1 |
| Desmadril, M | 1 |
| Takahashi, M | 1 |
| Aggerbeck, LP | 1 |
| Dabaghian, RH | 1 |
| Barnard, G | 1 |
| McConnell, I | 1 |
| Clewley, JP | 1 |
| Mason, PE | 1 |
| Dempsey, CE | 1 |
| Neilson, GW | 1 |
| Brady, JW | 1 |
| Xu, S | 1 |
| Ye, M | 1 |
| Xu, D | 1 |
| Li, X | 1 |
| Pan, C | 1 |
| Zou, H | 1 |
| Liang, L | 1 |
| Yao, P | 1 |
| Jiang, M | 1 |
| Kim, HH | 1 |
| Lee, YM | 1 |
| Suh, JK | 1 |
| Song, NW | 1 |
| Thongpanchang, C | 1 |
| Taweechai, S | 1 |
| Kamchonwongpaisan, S | 1 |
| Yuthavong, Y | 1 |
| Thebtaranonth, Y | 1 |
| Ahn, YH | 1 |
| Ji, ES | 1 |
| Lee, JY | 1 |
| Cho, K | 1 |
| Yoo, JS | 1 |
| Brancia, FL | 1 |
| Bereszczak, JZ | 1 |
| Piatkowska, E | 1 |
| Delneri, D | 1 |
| Hernandez-Folgado, L | 1 |
| Schmuck, C | 1 |
| Tomić, S | 1 |
| Piantanida, I | 1 |
| Brooks, SP | 1 |
| Lampi, BJ | 1 |
| Sarwar, G | 1 |
| Botting, HG | 1 |
| Levine, RL | 1 |
| Williams, JA | 1 |
| Stadtman, ER | 1 |
| Shacter, E | 1 |
| Björnsson, S | 1 |
| Doyle, DF | 1 |
| Waldner, JC | 1 |
| Parikh, S | 1 |
| Alcazar-Roman, L | 1 |
| Pielak, GJ | 1 |
| Funderburgh, JL | 1 |
| Prakash, S | 1 |
| Farmer, BT | 1 |
| Venters, RA | 1 |
| Sugiuchi, H | 1 |
| Uji, Y | 1 |
| Shirahase, Y | 1 |
| Okabe, H | 1 |
| Edwards, JT | 1 |
| Diegmann, MH | 1 |
| Scarborough, NL | 1 |
| Rewinkel, JB | 1 |
| Adang, AE | 1 |
| Ratner, V | 1 |
| Sinev, M | 1 |
| Haas, E | 1 |
| Peyman, A | 1 |
| Scheunemann, K | 1 |
| Will, DW | 1 |
| Knolle, J | 1 |
| Wehner, V | 1 |
| Breipohl, G | 1 |
| Stilz, HU | 1 |
| Carniato, D | 1 |
| Ruxer, J | 1 |
| Gourvest, J | 1 |
| Auberval, M | 1 |
| Doucet, B | 1 |
| Baron, R | 1 |
| Gaillard, M | 1 |
| Gadek, TR | 1 |
| Bodary, S | 1 |
| de Magalhães, VD | 1 |
| de Melo Azevedo, Fda P | 1 |
| Pasternak, J | 1 |
| Valle Martino, MD | 1 |
| Yamaguchi, M | 1 |
| Dieffenbach, CW | 1 |
| Connolly, R | 1 |
| Cruess, DF | 1 |
| Baur, W | 1 |
| Sharefkin, JB | 1 |
| Pepinsky, RB | 1 |
| Hunter, KJ | 1 |
| Fairlamb, AH | 1 |
1 review available for guanidine and Sensitivity and Specificity
| Article | Year |
|---|---|
Strategies and progress towards the ideal orally active thrombin inhibitor.
Topics: Administration, Oral; Amidines; Animals; Biological Availability; Clinical Trials as Topic; Fibrinol | 1999 |
43 other studies available for guanidine and Sensitivity and Specificity
| Article | Year |
|---|---|
Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo.
Topics: Animals; Contrast Media; Glioma; Guanidine; Heterografts; Humans; Mice; Molecular Imaging; Neoplasms | 2017 |
Characterization of a sandwich ELISA for quantification of total human soluble neuropilin-1.
Topics: Animals; Antibodies; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitopes; Guanidine; Humans | 2019 |
Guanidinated protein internal standard for immunoaffinity-liquid chromatography/tandem mass spectrometry quantitation of protein therapeutics.
Topics: Calibration; Chromatography, Affinity; Guanidine; Least-Squares Analysis; Peptide Fragments; Recombi | 2014 |
Novel guanidine-containing molecular transporters based on lactose scaffolds: lipophilicity effect on the intracellular organellar selectivity.
Topics: Guanidine; HeLa Cells; Humans; Lactose; Organelles; Sensitivity and Specificity | 2008 |
Efficient mycobacterial DNA extraction from clinical samples for early diagnosis of tuberculosis.
Topics: Adolescent; Adult; Aged; Benzyl Alcohol; Child; Child, Preschool; DNA, Bacterial; Early Diagnosis; F | 2010 |
Capillary electrophoresis analysis of inorganic cations in post-blast residue extracts applying a guanidinium-based electrolyte and bilayer-coated capillaries.
Topics: Cations; Electrophoresis, Capillary; Explosive Agents; Guanidine; Sensitivity and Specificity; Soil; | 2011 |
Nonlinear fluorescence response driven by ATP-induced self-assembly of guanidinium-tethered tetraphenylethene.
Topics: Adenosine Triphosphate; Biosensing Techniques; Fluorescence; Fluorescent Dyes; Guanidine; Sensitivit | 2012 |
Stochastic sensing of IP(3) has far-reaching consequences.
Topics: Biological Transport; Biosensing Techniques; Cell Membrane; Guanidine; Hemolysin Proteins; Inositol | 2002 |
Change in creep behavior of plexiform bone with phosphate ion treatment.
Topics: Animals; Cattle; Cetomacrogol; Elasticity; Electrophoresis; Femur; Guanidine; Humans; In Vitro Techn | 2003 |
Using analytical ultracentrifugation to study compositional variation in vertebrate genomes.
Topics: Animals; Centrifugation, Density Gradient; Cystine; DNA; DNA Mutational Analysis; Gene Expression Pr | 2003 |
Probing of arginine residues in peptides and proteins using selective tagging and electrospray ionization mass spectrometry.
Topics: Affinity Labels; Arginine; Guanidine; Peptides; Proteins; Sensitivity and Specificity; Spectrometry, | 2003 |
Polarographic behavior of Co(II)-BSA or -HSA complex in the presence of a guanidine modifier.
Topics: Adsorption; Amino Acids; Animals; Cattle; Cobalt; Guanidine; Humans; Hydrogen-Ion Concentration; Mur | 2003 |
Small amounts of urea and guanidine hydrochloride can be detected by a far-UV spectrophotometric method in dialysed protein solutions.
Topics: Complex Mixtures; Dialysis Solutions; Guanidine; Microchemistry; Proteins; Reference Values; Refract | 2004 |
Interactions of complementary PEGylated liposomes and characterization of the resulting aggregates.
Topics: Cholesterol; Guanidine; Ligands; Light; Liposomes; Macromolecular Substances; Molecular Structure; P | 2004 |
Quantification of sodium dodecyl sulfate in microliter biochemical samples by gas chromatography.
Topics: Animals; Cattle; Chromatography, Gas; Colorimetry; Dodecanol; Gas Chromatography-Mass Spectrometry; | 2004 |
An Eu(III) sensor based on N,N-diethyl-N-(4-hydroxy-6-methylpyridin-2-yl)guanidine.
Topics: Europium; Guanidine; Hydrogen-Ion Concentration; Ion-Selective Electrodes; Membranes, Artificial; Mo | 2004 |
Analysis of guanidine in high salt and protein matrices by cation-exchange chromatography and UV detection.
Topics: Cation Exchange Resins; Chromatography, Ion Exchange; Guanidine; Proteins; Salts; Sensitivity and Sp | 2005 |
Determination of Ophiopogon japonicus polysaccharide in plasma by HPLC with modified postcolumn fluorescence derivatization.
Topics: Animals; Chromatography, High Pressure Liquid; Fructans; Guanidine; Hydrogen-Ion Concentration; Male | 2005 |
Apparent pKa shifts of titratable residues at high denaturant concentration and the impact on protein stability.
Topics: Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Glutamic Acid; Guanidine; Histidine; Hydroge | 2005 |
The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure.
Topics: Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Chromatography, Gel; Cir | 2006 |
An immunoassay for the pathological form of the prion protein based on denaturation and time resolved fluorometry.
Topics: Brain; Brain Chemistry; Creutzfeldt-Jakob Syndrome; Fluorescent Antibody Technique; Fluorometry; Gua | 2006 |
Nanometer-scale ion aggregates in aqueous electrolyte solutions: guanidinium sulfate and guanidinium thiocyanate.
Topics: Electrolytes; Guanidine; Guanidines; Models, Molecular; Nanostructures; Neutron Diffraction; Sensiti | 2005 |
Matrix with high salt tolerance for the analysis of peptide and protein samples by desorption/ionization time-of-flight mass spectrometry.
Topics: Benzophenones; Cations; Guanidine; Insulin; Metals; Neurotensin; Peptides; Phenylenediamines; Protei | 2006 |
Reversibility of structural transition of cytochrome c on interacting with and releasing from alternating copolymers of maleic Acid and alkene.
Topics: Alkenes; Animals; Cytochromes c; Guanidine; Heart; Horses; Hydrogen-Ion Concentration; Maleates; Mic | 2006 |
Photodegradation mechanism and reaction kinetics of recombinant human interferon-alpha2a.
Topics: Circular Dichroism; Disulfides; Dithionitrobenzoic Acid; Glutathione; Guanidine; Humans; Interferon | 2007 |
Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Chromatography, High Pressure Liquid; Co | 2007 |
Arginine-mimic labeling with guanidinoethanethiol to increase mass sensitivity of lysine-terminated phosphopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Topics: Arginine; Guanidine; Lysine; Peptide Mapping; Phosphopeptides; Reproducibility of Results; Sensitivi | 2007 |
Development of novel guanidino-labelling derivatisation (GLaD) reagents for liquid chromatography/matrix-assisted laser desorption/ionisation analysis.
Topics: Chromatography, High Pressure Liquid; Guanidine; Indicators and Reagents; Peptide Mapping; Proteins; | 2007 |
A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods.
Topics: Cations; DNA; Fluorescent Dyes; Guanidine; Intercalating Agents; Nucleic Acid Conformation; Pyrenes; | 2008 |
A comparison of methods for determining total body protein.
Topics: Amino Acids; Animals; Biuret Reaction; Body Constitution; Caseins; Cell Extracts; Chemistry Techniqu | 1995 |
Carbonyl assays for determination of oxidatively modified proteins.
Topics: Aldehydes; Animals; Blotting, Western; Chromatography, Gel; Chromatography, High Pressure Liquid; Es | 1994 |
Simultaneous preparation and quantitation of proteoglycans by precipitation with alcian blue.
Topics: Alcian Blue; Animals; Cattle; Chemical Precipitation; Detergents; Glycosaminoglycans; Guanidine; Gua | 1993 |
Changing the transition state for protein (Un) folding.
Topics: Asparagine; Calorimetry; Circular Dichroism; Cytochrome c Group; Cytochromes c; Genetic Variation; G | 1996 |
SDS-polyacrylamide gel electrophoretic analysis of proteins in the presence of guanidinium hydrochloride.
Topics: Animals; Cattle; Electrophoresis, Polyacrylamide Gel; Guanidine; Guanidines; Protein Denaturation; P | 1996 |
Assignment of aliphatic side-chain 1HN/15N resonances in perdeuterated proteins.
Topics: Amino Acid Sequence; Amino Acids; Arginine; Asparagine; Deuterium; Glutamine; Guanidine; Guanidines; | 1996 |
A novel automated assay for malate dehydrogenase isoenzymes.
Topics: Adult; Coenzymes; Electrophoresis; Female; Guanidine; Guanidines; Humans; Hydrogen-Ion Concentration | 1996 |
Osteoinduction of human demineralized bone: characterization in a rat model.
Topics: Animals; Bone Demineralization Technique; Bone Matrix; Female; Guanidine; Methods; Models, Biologica | 1998 |
Determination of intramolecular distance distribution during protein folding on the millisecond timescale.
Topics: Adenylate Kinase; Diffusion; Energy Transfer; Escherichia coli; Fluorescence Polarization; Guanidine | 2000 |
alpha(v)beta(3) Antagonists based on a central thiophene scaffold.
Topics: Animals; Binding Sites; Carbamates; Cell Adhesion; Cells, Cultured; Disease Models, Animal; Dose-Res | 2001 |
Reliability of hsp65-RFLP analysis for identification of Mycobacterium species in cultured strains and clinical specimens.
Topics: Antigens, Bacterial; Bacterial Proteins; Bacterial Typing Techniques; Bronchoalveolar Lavage Fluid; | 2002 |
Effect of different laboratory techniques for guanidinium-phenol-chloroform RNA extraction on A260/A280 and on accuracy of mRNA quantitation by reverse transcriptase-PCR.
Topics: Base Sequence; Cells, Cultured; Chloroform; DNA; Endothelium, Vascular; Guanidine; Guanidines; Human | 1992 |
Selective precipitation of proteins from guanidine hydrochloride-containing solutions with ethanol.
Topics: Bacterial Proteins; Chemical Precipitation; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel | 1991 |
Separation and quantitation of the polyamine biosynthesis inhibitor D,L-alpha-difluoromethylarginine and other guanidine-containing compounds by high-performance liquid chromatography.
Topics: Animals; Arginine; Carboxy-Lyases; Chromatography, High Pressure Liquid; Crithidia; Fluorescent Dyes | 1990 |