guanidine has been researched along with Protein Aggregation, Pathological in 1 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lazarev, VF | 1 |
| Nikotina, AD | 1 |
| Semenyuk, PI | 1 |
| Evstafyeva, DB | 1 |
| Mikhaylova, ER | 1 |
| Muronetz, VI | 1 |
| Shevtsov, MA | 1 |
| Tolkacheva, AV | 1 |
| Dobrodumov, AV | 1 |
| Shavarda, AL | 1 |
| Guzhova, IV | 1 |
| Margulis, BA | 1 |
1 other study available for guanidine and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress.
Topics: Animals; Cell Death; Cell Line, Tumor; Cholestanols; Glyceraldehyde-3-Phosphate Dehydrogenases; Guan | 2016 |