guanidine has been researched along with Parkinson Disease in 2 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pham, CL | 1 |
| Kirby, N | 1 |
| Wood, K | 1 |
| Ryan, T | 1 |
| Roberts, B | 1 |
| Sokolova, A | 1 |
| Barnham, KJ | 1 |
| Masters, CL | 1 |
| Knott, RB | 1 |
| Cappai, R | 1 |
| Curtain, CC | 1 |
| Rekas, A | 1 |
| Ecroyd, H | 1 |
| Carver, JA | 1 |
2 other studies available for guanidine and Parkinson Disease
| Article | Year |
|---|---|
Guanidine hydrochloride denaturation of dopamine-induced α-synuclein oligomers: a small-angle X-ray scattering study.
Topics: alpha-Synuclein; Brain; Cluster Analysis; Dopamine; Electrophoresis, Polyacrylamide Gel; Escherichia | 2014 |
The effect of small molecules in modulating the chaperone activity of alphaB-crystallin against ordered and disordered protein aggregation.
Topics: alpha-Crystallin B Chain; alpha-Synuclein; Amyloid; Animals; Arginine; Caseins; Cattle; Cytoprotecti | 2008 |