guanidine has been researched along with Neuroblastoma in 24 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Meta-iodobenzylguanidine(MIBG) scans are used to detect neuroblastoma metastatic lesions at diagnosis and during posttreatment surveillance." | 8.02 | Residual meta-iodobenzyl guanidine (MIBG) positivity following therapy for metastatic neuroblastoma: Patient characteristics, imaging, and outcome. ( Deyell, RJ; Farfan, M; Irwin, MS; Moorehead, PC; Morgenstern, DA; Portwine, C; Rafael, MS; Shammas, A; Usmani, N; Vali, R; Vanniyasingam, T, 2021) |
| "The ability of G protein-coupled receptors to regulate osmosensitive uptake of the organic osmolyte, taurine, into human SH-SY5Y neuroblastoma cells has been examined." | 7.75 | Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. ( Banerjee, R; Fisher, SK; Foster, DJ; Heacock, AM; Vitvitsky, VM, 2009) |
| "Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0." | 7.66 | Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983) |
| "Meta-iodobenzylguanidine(MIBG) scans are used to detect neuroblastoma metastatic lesions at diagnosis and during posttreatment surveillance." | 4.02 | Residual meta-iodobenzyl guanidine (MIBG) positivity following therapy for metastatic neuroblastoma: Patient characteristics, imaging, and outcome. ( Deyell, RJ; Farfan, M; Irwin, MS; Moorehead, PC; Morgenstern, DA; Portwine, C; Rafael, MS; Shammas, A; Usmani, N; Vali, R; Vanniyasingam, T, 2021) |
| "The ability of G protein-coupled receptors to regulate osmosensitive uptake of the organic osmolyte, taurine, into human SH-SY5Y neuroblastoma cells has been examined." | 3.75 | Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. ( Banerjee, R; Fisher, SK; Foster, DJ; Heacock, AM; Vitvitsky, VM, 2009) |
| "Studies were conducted using a novel in vitro approach to investigate the efficacy of acetamidine hydrochloride (ACE) and guanidine hydrochloride (GUAN), previously shown to block gramicidin D (GRAM) channels in artificial membranes, in preventing the toxic effects of GRAM in NG108-15 (neuroblastoma x glioma hybrid) cells." | 3.70 | Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine. ( Doebler, JA, 1999) |
| "N1E-115 mouse neuroblastoma cells were used to study the influence of ethanol on the 5-HT- and veratridine-induced influx of 14C-guanidinium via the 5-HT3 receptor channel and the fast sodium channel, respectively." | 3.69 | Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells. ( Barann, M; Bönisch, H; Göthert, M; Ruppert, K, 1995) |
| "The influence of local and general anaesthetics on cation influx through the fast, voltage-dependent sodium channel and the 5-HT3 receptor cation channel was studied in N1E-115 mouse neuroblastoma cells by measuring 2-min influx of the organic cation 14C-guanidinium induced by either veratridine (1 mmol/l) or 5-HT (100 mumol/l)." | 3.68 | Inhibition by anaesthetics of 14C-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells. ( Barann, M; Bönisch, H; Fink, K; Göthert, M, 1993) |
| "In the presence of substance P (SP; 10 microM), serotonin (5-HT; 1 microM) triggered a cation permeability in cells of the hybridoma (mouse neuroblastoma x rat glioma) clone NG 108-15 that could be assessed by measuring the cell capacity to accumulate [14C]guanidinium for 10-15 min at 37 degrees C." | 3.68 | Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P. ( Emerit, MB; Fattaccini, CM; Hamon, M; Riad, M, 1993) |
| "Substance P at micromolar concentrations enhances the uptake of [14C]guanidinium in neuroblastoma X glioma hybrid cells, an effect which most likely indicates activation of Na+ permeability." | 3.67 | Characterization of a substance P receptor activating a cation permeability in neuronal cell lines. ( Hamprecht, B; Reiser, G, 1988) |
| "Both substance P and, to a lesser degree, serotonin activate cation permeability in neuroblastoma x glioma hybrid cells, as determined by measurement of [14C]guanidinium uptake." | 3.67 | Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line. ( Hamprecht, B; Reiser, G, 1989) |
| " Therefore, the veratridine- (or aconitine-)stimulated influx of [14C]guanidinium in neuroblastoma x glioma hybrid cells was measured to characterize the Na+ ionophore of these cells." | 3.66 | Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines. ( Günther, A; Hamprecht, B; Reiser, G, 1983) |
| "Substance P stimulated the uptake of guanidinium in neuroblastoma X glioma hybrid cells and neuroblastoma cells but not in polyploid glioma cells." | 3.66 | Substance P enhances cation permeability of neuronal cell lines. ( Folkers, K; Hamprecht, B; Reiser, G, 1982) |
| "Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0." | 3.66 | Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (33.33) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sakashita, T | 1 |
| Watanabe, S | 1 |
| Hanaoka, H | 1 |
| Ohshima, Y | 1 |
| Ikoma, Y | 1 |
| Ukon, N | 1 |
| Sasaki, I | 1 |
| Higashi, T | 1 |
| Higuchi, T | 1 |
| Tsushima, Y | 1 |
| Ishioka, NS | 1 |
| Usmani, N | 1 |
| Deyell, RJ | 1 |
| Portwine, C | 1 |
| Rafael, MS | 1 |
| Moorehead, PC | 1 |
| Shammas, A | 1 |
| Vali, R | 1 |
| Farfan, M | 1 |
| Vanniyasingam, T | 1 |
| Morgenstern, DA | 1 |
| Irwin, MS | 1 |
| Lazarev, VF | 1 |
| Nikotina, AD | 1 |
| Semenyuk, PI | 1 |
| Evstafyeva, DB | 1 |
| Mikhaylova, ER | 1 |
| Muronetz, VI | 1 |
| Shevtsov, MA | 1 |
| Tolkacheva, AV | 1 |
| Dobrodumov, AV | 1 |
| Shavarda, AL | 1 |
| Guzhova, IV | 1 |
| Margulis, BA | 1 |
| Foster, DJ | 1 |
| Vitvitsky, VM | 1 |
| Banerjee, R | 1 |
| Heacock, AM | 1 |
| Fisher, SK | 1 |
| Keller, M | 1 |
| Bernhardt, G | 1 |
| Buschauer, A | 1 |
| Reiser, G | 6 |
| Günther, A | 2 |
| Hamprecht, B | 6 |
| Folkers, K | 1 |
| Barann, M | 5 |
| Ruppert, K | 1 |
| Göthert, M | 6 |
| Bönisch, H | 6 |
| Graupner, J | 1 |
| Fink, K | 1 |
| Emerit, MB | 2 |
| Riad, M | 2 |
| Fattaccini, CM | 1 |
| Hamon, M | 3 |
| Cappelli, A | 1 |
| Anzini, M | 1 |
| Vomero, S | 1 |
| Mennuni, L | 1 |
| Makovec, F | 1 |
| Doucet, E | 1 |
| Bruni, G | 1 |
| Romeo, MR | 1 |
| Menziani, MC | 1 |
| De Benedetti, PG | 1 |
| Langer, T | 1 |
| Urban, BW | 1 |
| Brüss, M | 1 |
| Cubeddu, LX | 1 |
| Molderings, G | 1 |
| Racké, K | 1 |
| Ramadori, G | 1 |
| Miller, KJ | 1 |
| Schwörer, H | 1 |
| Doebler, JA | 1 |
| Gossen, D | 1 |
| Gesquière, JC | 1 |
| Tastenoy, M | 1 |
| De Neef, P | 1 |
| Waelbroeck, M | 1 |
| Christophe, J | 1 |
| Tas, PW | 2 |
| Kress, HG | 2 |
| Koschel, K | 2 |
24 other studies available for guanidine and Neuroblastoma
| Article | Year |
|---|---|
Absorbed dose simulation of meta-
Topics: 3-Iodobenzylguanidine; Guanidine; Half-Life; Humans; Monte Carlo Method; Neuroblastoma; Radiation Do | 2021 |
Residual meta-iodobenzyl guanidine (MIBG) positivity following therapy for metastatic neuroblastoma: Patient characteristics, imaging, and outcome.
Topics: 3-Iodobenzylguanidine; Guanidine; Humans; N-Myc Proto-Oncogene Protein; Neoplasm Recurrence, Local; | 2021 |
Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress.
Topics: Animals; Cell Death; Cell Line, Tumor; Cholestanols; Glyceraldehyde-3-Phosphate Dehydrogenases; Guan | 2016 |
Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells.
Topics: Alanine; Antioxidants; Biological Transport; Calcium; Cell Line, Tumor; Cyclopentanes; Dose-Response | 2009 |
[³H]UR-MK136: a highly potent and selective radioligand for neuropeptide Y Y₁ receptors.
Topics: Acetylation; Arginine; Cell Line; Diphenylacetic Acids; Guanidine; Humans; Kinetics; Neuroblastoma; | 2011 |
Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines.
Topics: Animals; Atropine; Calcium; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; Ki | 1983 |
Substance P enhances cation permeability of neuronal cell lines.
Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; | 1982 |
Strychnine and local anesthetics block ion channels activated by veratridine in neuroblastoma x glioma hybrid cells.
Topics: Anesthetics, Local; Animals; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; K | 1982 |
Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport.
Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; | 1983 |
Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells.
Topics: Alcohols; Animals; Binding, Competitive; Brain Neoplasms; Ethanol; Guanidine; Guanidines; Imidazoles | 1995 |
Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidinium.
Topics: Animals; Calcium; Carbon Radioisotopes; Guanidine; Guanidines; Mice; Neuroblastoma; Neurons; Radioli | 1993 |
Inhibition by anaesthetics of 14C-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells.
Topics: Anesthesia, General; Anesthetics; Anesthetics, Local; Animals; Carbon Radioisotopes; Guanidine; Guan | 1993 |
Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P.
Topics: Animals; Benzamides; Biological Transport; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Het | 1993 |
Pharmacological evidence for the involvement of calcium/calmodulin in serotonin 5-HT3 receptor-mediated cation permeability in NG 108-15 cells.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Ca | 1994 |
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
Topics: Animals; Benzene; Binding Sites; Glioma; Guanidine; Mice; Models, Molecular; Molecular Structure; Ne | 1998 |
Inhibition by propofol of 5-HT3 receptors in excised patches of NIE-115 cells.
Topics: Animals; Carbon Radioisotopes; Guanidine; Kinetics; Neuroblastoma; Patch-Clamp Techniques; Propofol; | 1998 |
Inhibition by steroids of [14C]-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells.
Topics: Animals; Carbon Radioisotopes; Cations; Dexamethasone; Dose-Response Relationship, Drug; Drug Intera | 1999 |
Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Chromatography, High Pressure Liquid; Duodenum; Entero | 2000 |
Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine.
Topics: Amidines; Animals; Anti-Bacterial Agents; Drug Interactions; Electric Impedance; Electrophysiology; | 1999 |
Characterization and regulation of the expression of scyllatoxin (Leiurotoxin I) receptors in the human neuroblastoma cell line NB-OK 1.
Topics: Amino Acid Sequence; Apamin; Butyrates; Butyric Acid; Calcium; Cell Membrane; Cycloheximide; Gene Ex | 1991 |
Characterization of a substance P receptor activating a cation permeability in neuronal cell lines.
Topics: Glioma; Guanidine; Guanidines; Hybrid Cells; Neuroblastoma; Neurons; Receptors, Neurokinin-1; Recept | 1988 |
Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line.
Topics: Catecholamines; Cations; Cell Line; Cell Membrane Permeability; Drug Interactions; Glioma; Guanidine | 1989 |
The sodium channels of the neuroblastoma x glioma 108 CC 15 hybrid cell change their sensitivity for volatile and local anesthetics upon continuous passage.
Topics: Anesthetics; Animals; Glioma; Guanidine; Guanidines; Halothane; Hybridomas; Isoflurane; Neuroblastom | 1989 |
Halothane inhibits the neurotoxin stimulated [14C]guanidinium influx through 'silent' sodium channels in rat glioma C6 cells.
Topics: Aconitine; Animals; Cell Line; Drug Synergism; Glioma; Guanidine; Guanidines; Halothane; Ion Channel | 1985 |