guanidine has been researched along with Muscular Dystrophy, Duchenne in 2 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (50.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Morcos, PA | 1 |
Li, Y | 1 |
Jiang, S | 1 |
Kang, JK | 1 |
Malerba, A | 1 |
Popplewell, L | 1 |
Foster, K | 1 |
Dickson, G | 1 |
2 other studies available for guanidine and Muscular Dystrophy, Duchenne
Article | Year |
---|---|
Vivo-Morpholinos: a non-peptide transporter delivers Morpholinos into a wide array of mouse tissues.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Drug Delivery Systems; Dystrophin; Fluorescent Ant | 2008 |
Antisense-induced myostatin exon skipping leads to muscle hypertrophy in mice following octa-guanidine morpholino oligomer treatment.
Topics: Animals; Cell Proliferation; Cells, Cultured; Exons; Genetic Therapy; Guanidine; Hypertrophy; Mice; | 2011 |