guanidine has been researched along with Muscle Contraction in 13 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The myonecrosis induced by guanidine in the mouse phrenic nerve diaphragm preparation was investigated using both light microscopy and myographic recordings." | 7.69 | Myonecrosis induced by guanidine in the mouse isolated phrenic nerve diaphragm preparation. ( Corrado, AP; Cruz-Höfling, MA; Leite, GB; Rodrigues-Simioni, L; Silva-Carvalho, I, 1997) |
| " The myonecrosis induced by guanidine in the mouse phrenic nerve diaphragm preparation was investigated using both light microscopy and myographic recordings." | 3.69 | Myonecrosis induced by guanidine in the mouse isolated phrenic nerve diaphragm preparation. ( Corrado, AP; Cruz-Höfling, MA; Leite, GB; Rodrigues-Simioni, L; Silva-Carvalho, I, 1997) |
| "In the isolated phrenic nerve-hemidiaphragm preparation from the rat, thallium acetate induced a dose-dependent irreversible paralysis." | 3.67 | The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation. ( Csicsaky, M; Krämer, U; Wiegand, H, 1984) |
| "Guanidine has been used with some success to treat myasthenia gravis and myasthenic syndrome because it increases acetylcholine release at nerve terminals through K⁺, Na⁺ and Ca²⁺ channels-involving mechanisms." | 1.38 | Guanidine affects differentially the twitch response of diaphragm, extensor digitorum longus and soleus nerve-muscle preparations of mice. ( da Cruz Höfling, MA; Ferrari, R; Rodrigues-Simioni, L, 2012) |
| "The guanidine-induced NMB was reverted by increasing the Ca2+ concentration (1." | 1.30 | Novel effects of guanidine on the neuromuscular junction. ( Ballejo, G; Corrado, AP; Cruz-Höfling, MA; Heluany, NF; Leite, GB; Prado-Franceschi, J; Rodrigues-Simioni, L; Silva-Carvalho, I, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Enzensperger, C | 1 |
| Lehmann, J | 1 |
| von Schroetter, K | 1 |
| Riyazi, A | 1 |
| Verspohl, EJ | 1 |
| Widrick, JJ | 1 |
| Jiang, S | 1 |
| Choi, SJ | 1 |
| Knuth, ST | 1 |
| Morcos, PA | 1 |
| Ferrari, R | 1 |
| Rodrigues-Simioni, L | 3 |
| da Cruz Höfling, MA | 1 |
| Dardonville, C | 2 |
| Rozas, I | 2 |
| Goya, P | 2 |
| Girón, R | 1 |
| Goicoechea, C | 1 |
| Martín, MI | 2 |
| Wiegand, H | 1 |
| Csicsaky, M | 1 |
| Krämer, U | 1 |
| Lee, HH | 2 |
| Shyu, LY | 1 |
| Terada, M | 2 |
| Chen, W | 1 |
| Wang, HH | 1 |
| Kachi, S | 1 |
| Cruz-Höfling, MA | 2 |
| Silva-Carvalho, I | 2 |
| Leite, GB | 2 |
| Corrado, AP | 2 |
| Heluany, NF | 1 |
| Prado-Franceschi, J | 1 |
| Ballejo, G | 1 |
| Alsasua, A | 1 |
| Borrego, MJ | 1 |
| Andreani, A | 1 |
| Leoni, A | 1 |
| Locatelli, A | 1 |
| Morigi, R | 1 |
| Rambaldi, M | 1 |
| Recanatini, M | 1 |
| Garaliene, V | 1 |
| Sharma, SK | 1 |
| Jones, RM | 1 |
| Metzger, TG | 1 |
| Ferguson, DM | 1 |
| Portoghese, PS | 1 |
| Feldmeyer, D | 1 |
| Csernoch, L | 1 |
| Kovács, L | 1 |
| Thieleczek, R | 1 |
13 other studies available for guanidine and Muscle Contraction
| Article | Year |
|---|---|
Arylalkylamine-, beta-carboline-, quinolizine- and azecine-derived compounds and their in vitro interaction with the ionotropic 5-HT3 receptor: search for new lead structures.
Topics: Amines; Animals; Carbolines; Cations; Cell Line; Drug Discovery; Female; Gastrointestinal Agents; Gu | 2010 |
An octaguanidine-morpholino oligo conjugate improves muscle function of mdx mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dystrophin; Electric Stimulation; Gene Expres | 2011 |
Guanidine affects differentially the twitch response of diaphragm, extensor digitorum longus and soleus nerve-muscle preparations of mice.
Topics: Animals; Calcium; Diaphragm; Guanidine; Male; Mice; Muscle Contraction; Muscle, Skeletal; Myography; | 2012 |
Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Aza Compounds; Biological Availability; Dose-Respons | 2003 |
The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Diaphragm; Female; Guanidine; Guanidines; Kinetic | 1984 |
In vitro effects of VD-99-11 on Angiostrongylus cantonensis and isolated frog rectus.
Topics: Angiostrongylus cantonensis; Animals; Antinematodal Agents; Bicuculline; Female; Guanidine; Guanidin | 1995 |
Effects of gabergic anthelmintics at higher concentrations on the guanidine-induced twitch responses in isolated frog rectus preparations.
Topics: Acetylcholine; Animals; Anthelmintics; Anti-Bacterial Agents; gamma-Aminobutyric Acid; Guanidine; Gu | 1994 |
Myonecrosis induced by guanidine in the mouse isolated phrenic nerve diaphragm preparation.
Topics: Animals; Diaphragm; Electric Stimulation; Guanidine; Guanidines; In Vitro Techniques; Male; Mice; Mu | 1997 |
Novel effects of guanidine on the neuromuscular junction.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Calcium; Chickens; Cromakalim; Electric Stimulation; Electrom | 1997 |
New aromatic iminoimidazolidine derivatives as alpha1-adrenoceptor antagonists: a novel synthetic approach and pharmacological activity.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Bradykinin; Dose-Response Relationship, Drug | 2000 |
Potential antitumor agents. Part 29(1): synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones.
Topics: Animals; Antineoplastic Agents; CDC2 Protein Kinase; Cell Division; Cell Survival; Guanidine; Guinea | 2000 |
Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole.
Topics: Animals; Cell Line; Cloning, Molecular; Guanidine; Guinea Pigs; Humans; In Vitro Techniques; Molecul | 2001 |
Effects of guanidinium on EC coupling and tension generation in frog skeletal muscle.
Topics: Animals; Calcium; Guanidine; Guanidines; Membrane Potentials; Muscle Contraction; Muscles; Rana escu | 1988 |