guanidine has been researched along with Multiple Myeloma in 4 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amet, R | 1 |
| Previtali, V | 1 |
| Mihigo, HB | 1 |
| Sheridan, E | 1 |
| Brophy, S | 1 |
| Hante, NK | 1 |
| Santos-Martinez, MJ | 1 |
| Hayden, PJ | 1 |
| Browne, PV | 1 |
| Rozas, I | 1 |
| McElligott, AM | 1 |
| Zisterer, DM | 1 |
| Gallango, ML | 1 |
| Caldera, LH | 1 |
| Suinaga, R | 1 |
| RamÃrez, M | 1 |
| Goto, Y | 2 |
| Hamaguchi, K | 2 |
| Tsunenaga, M | 1 |
| Kawata, Y | 1 |
4 other studies available for guanidine and Multiple Myeloma
| Article | Year |
|---|---|
A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Gene Expression; Gene Expression | 2022 |
Co-occurrence of albumin complexes with IgE and IgG in the serum of an IgE myeloma patient.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gel; Electrophoresis, Cellulose Acetate; Guanidine; G | 1982 |
Role of amino-terminal residues in the folding of the constant fragment of the immunoglobulin light chain.
Topics: Amino Acid Sequence; Circular Dichroism; Guanidine; Guanidines; Humans; Hydrogen-Ion Concentration; | 1987 |
Unfolding and refolding of a type kappa immunoglobulin light chain and its variable and constant fragments.
Topics: Amino Acid Sequence; Amino Acids; Bence Jones Protein; Circular Dichroism; Guanidine; Guanidines; Hu | 1987 |