guanidine has been researched along with Lambert-Eaton Myasthenic Syndrome in 10 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Lambert-Eaton Myasthenic Syndrome: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Guanidine hydrochloride is known to be highly effective in the symptomatic treatment of the Lambert-Eaton myasthenic syndrome (LEMS)." | 9.08 | Low-dose guanidine and pyridostigmine: relatively safe and effective long-term symptomatic therapy in Lambert-Eaton myasthenic syndrome. ( Claussen, GC; Head, TC; Kim, DS; Oh, SJ, 1997) |
| "Guanidine hydrochloride is known to be highly effective in the symptomatic treatment of the Lambert-Eaton myasthenic syndrome (LEMS)." | 5.08 | Low-dose guanidine and pyridostigmine: relatively safe and effective long-term symptomatic therapy in Lambert-Eaton myasthenic syndrome. ( Claussen, GC; Head, TC; Kim, DS; Oh, SJ, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (70.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oh, SJ | 3 |
| Maddison, P | 1 |
| Verschuuren, JJ | 1 |
| Wirtz, PW | 1 |
| Titulaer, MJ | 1 |
| Willems, LN | 1 |
| van Gerven, J | 1 |
| Kim, DS | 2 |
| Head, TC | 1 |
| Claussen, GC | 2 |
| Kwon, KH | 1 |
| Tseng, A | 1 |
| Mussell, H | 1 |
| Jost, WH | 1 |
| Mielke, U | 1 |
| Schimrigk, K | 1 |
| Engler, F | 1 |
| Lundh, H | 1 |
| Nilsson, O | 1 |
| Rosén, I | 1 |
| Silbert, PL | 1 |
| Hankey, GJ | 1 |
| Barr, AL | 1 |
| Sahashi, K | 1 |
5 reviews available for guanidine and Lambert-Eaton Myasthenic Syndrome
| Article | Year |
|---|---|
Amifampridine for the treatment of Lambert-Eaton myasthenic syndrome.
Topics: Amifampridine; Cholinesterase Inhibitors; Drug and Narcotic Control; Guanidine; Humans; Lambert-Eato | 2019 |
Treatment in Lambert-Eaton myasthenic syndrome.
Topics: 4-Aminopyridine; Amifampridine; Antineoplastic Agents; Guanidine; Humans; Immunoglobulins, Intraveno | 2012 |
Available treatment options for the management of Lambert-Eaton myasthenic syndrome.
Topics: 4-Aminopyridine; Antineoplastic Agents; Carcinoma, Small Cell; Cholinesterase Inhibitors; Cisplatin; | 2006 |
[Lambert-Eaton myasthenia syndrome--review with case report].
Topics: Autonomic Nervous System Diseases; Carcinoma, Small Cell; Guanidine; Guanidines; Humans; Lambert-Eat | 1990 |
Current therapy of the Lambert-Eaton myasthenic syndrome.
Topics: Aminopyridines; Guanidine; Guanidines; Humans; Immunosuppressive Agents; Immunotherapy; Lambert-Eato | 1990 |
1 trial available for guanidine and Lambert-Eaton Myasthenic Syndrome
| Article | Year |
|---|---|
Low-dose guanidine and pyridostigmine: relatively safe and effective long-term symptomatic therapy in Lambert-Eaton myasthenic syndrome.
Topics: Adult; Aged; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophysiology; Female; | 1997 |
4 other studies available for guanidine and Lambert-Eaton Myasthenic Syndrome
| Article | Year |
|---|---|
Wide spectrum of symptomatic treatment in Lambert-Eaton myasthenic syndrome.
Topics: 4-Aminopyridine; Adult; Aged; Amifampridine; Carcinoma, Small Cell; Female; Guanidine; Humans; Lambe | 1998 |
Therapeutic approaches to Lambert-Eaton myasthenic syndrome in the intra-individual comparison.
Topics: 4-Aminopyridine; Amifampridine; Combined Modality Therapy; Electromyography; Follow-Up Studies; Guan | 1991 |
Successful alternate day guanidine therapy following guanidine-induced neutropenia in the Lambert-Eaton myasthenic syndrome.
Topics: Agranulocytosis; Drug Administration Schedule; Electromyography; Female; Guanidine; Guanidines; Huma | 1990 |
[Lambert-Eaton myasthenic syndrome].
Topics: 4-Aminopyridine; Adolescent; Adult; Aged; Amifampridine; Antibodies, Antinuclear; Child; Electromyog | 1990 |