guanidine has been researched along with HIV in 3 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Short basic peptides from the HIV Tat protein bind specifically to a bulge region in TAR RNA, with a single arginine residue providing the only sequence-specific contact." | 3.68 | Circular dichroism studies suggest that TAR RNA changes conformation upon specific binding of arginine or guanidine. ( Frankel, AD; Tan, R, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Wang, Y | 1 |
| Li, Z | 1 |
| Zhan, P | 1 |
| Bai, R | 1 |
| Pannecouque, C | 1 |
| Balzarini, J | 1 |
| De Clercq, E | 1 |
| Liu, X | 1 |
| Harada, K | 1 |
| Frankel, AD | 2 |
| Tan, R | 1 |
3 other studies available for guanidine and HIV
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction.
Topics: Anti-HIV Agents; Dose-Response Relationship, Drug; Drug Design; Guanidine; HIV; Indoles; Microbial S | 2014 |
Identification of two novel arginine binding DNAs.
Topics: Arginine; Base Sequence; Binding Sites; Chromatography, Affinity; Circular Dichroism; DNA Footprinti | 1995 |
Circular dichroism studies suggest that TAR RNA changes conformation upon specific binding of arginine or guanidine.
Topics: Amino Acid Sequence; Arginine; Bacteriophage T7; Base Sequence; Binding Sites; Circular Dichroism; D | 1992 |