guanidine and Glioma
guanidine has been researched along with Glioma in 13 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0." | 7.66 | Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983) |
| "Studies were conducted using a novel in vitro approach to investigate the efficacy of acetamidine hydrochloride (ACE) and guanidine hydrochloride (GUAN), previously shown to block gramicidin D (GRAM) channels in artificial membranes, in preventing the toxic effects of GRAM in NG108-15 (neuroblastoma x glioma hybrid) cells." | 3.70 | Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine. ( Doebler, JA, 1999) |
| "In the presence of substance P (SP; 10 microM), serotonin (5-HT; 1 microM) triggered a cation permeability in cells of the hybridoma (mouse neuroblastoma x rat glioma) clone NG 108-15 that could be assessed by measuring the cell capacity to accumulate [14C]guanidinium for 10-15 min at 37 degrees C." | 3.68 | Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P. ( Emerit, MB; Fattaccini, CM; Hamon, M; Riad, M, 1993) |
| "Substance P at micromolar concentrations enhances the uptake of [14C]guanidinium in neuroblastoma X glioma hybrid cells, an effect which most likely indicates activation of Na+ permeability." | 3.67 | Characterization of a substance P receptor activating a cation permeability in neuronal cell lines. ( Hamprecht, B; Reiser, G, 1988) |
| "Both substance P and, to a lesser degree, serotonin activate cation permeability in neuroblastoma x glioma hybrid cells, as determined by measurement of [14C]guanidinium uptake." | 3.67 | Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line. ( Hamprecht, B; Reiser, G, 1989) |
| " Therefore, the veratridine- (or aconitine-)stimulated influx of [14C]guanidinium in neuroblastoma x glioma hybrid cells was measured to characterize the Na+ ionophore of these cells." | 3.66 | Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines. ( Günther, A; Hamprecht, B; Reiser, G, 1983) |
| "Substance P stimulated the uptake of guanidinium in neuroblastoma X glioma hybrid cells and neuroblastoma cells but not in polyploid glioma cells." | 3.66 | Substance P enhances cation permeability of neuronal cell lines. ( Folkers, K; Hamprecht, B; Reiser, G, 1982) |
| "Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0." | 3.66 | Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983) |
Research
Studies (13)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Márquez, M | 1 |
| Olausson, KH | 1 |
| Alaiya, A | 1 |
| Nilsson, S | 1 |
| Meurling, L | 1 |
| Holmberg, AR | 1 |
| Johansen, ML | 1 |
| Gao, Y | 1 |
| Hutnick, MA | 1 |
| Craig, SEL | 1 |
| Pokorski, JK | 1 |
| Flask, CA | 1 |
| Brady-Kalnay, SM | 1 |
| Reiser, G | 6 |
| Günther, A | 2 |
| Hamprecht, B | 6 |
| Folkers, K | 1 |
| Emerit, MB | 1 |
| Riad, M | 1 |
| Fattaccini, CM | 1 |
| Hamon, M | 2 |
| Cappelli, A | 1 |
| Anzini, M | 1 |
| Vomero, S | 1 |
| Mennuni, L | 1 |
| Makovec, F | 1 |
| Doucet, E | 1 |
| Bruni, G | 1 |
| Romeo, MR | 1 |
| Menziani, MC | 1 |
| De Benedetti, PG | 1 |
| Langer, T | 1 |
| Doebler, JA | 1 |
| Tas, PW | 2 |
| Kress, HG | 2 |
| Koschel, K | 2 |
Other Studies
13 other studies available for guanidine and Glioma
| Article | Year |
|---|---|
Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells.
Topics: Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioblastoma; | 2022 |
Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo.
Topics: Animals; Contrast Media; Glioma; Guanidine; Heterografts; Humans; Mice; Molecular Imaging; Neoplasms | 2017 |
Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines.
Topics: Animals; Atropine; Calcium; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; Ki | 1983 |
Substance P enhances cation permeability of neuronal cell lines.
Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; | 1982 |
Strychnine and local anesthetics block ion channels activated by veratridine in neuroblastoma x glioma hybrid cells.
Topics: Anesthetics, Local; Animals; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; K | 1982 |
Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport.
Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; | 1983 |
Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P.
Topics: Animals; Benzamides; Biological Transport; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Het | 1993 |
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
Topics: Animals; Benzene; Binding Sites; Glioma; Guanidine; Mice; Models, Molecular; Molecular Structure; Ne | 1998 |
Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine.
Topics: Amidines; Animals; Anti-Bacterial Agents; Drug Interactions; Electric Impedance; Electrophysiology; | 1999 |
Characterization of a substance P receptor activating a cation permeability in neuronal cell lines.
Topics: Glioma; Guanidine; Guanidines; Hybrid Cells; Neuroblastoma; Neurons; Receptors, Neurokinin-1; Recept | 1988 |
Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line.
Topics: Catecholamines; Cations; Cell Line; Cell Membrane Permeability; Drug Interactions; Glioma; Guanidine | 1989 |
The sodium channels of the neuroblastoma x glioma 108 CC 15 hybrid cell change their sensitivity for volatile and local anesthetics upon continuous passage.
Topics: Anesthetics; Animals; Glioma; Guanidine; Guanidines; Halothane; Hybridomas; Isoflurane; Neuroblastom | 1989 |
Halothane inhibits the neurotoxin stimulated [14C]guanidinium influx through 'silent' sodium channels in rat glioma C6 cells.
Topics: Aconitine; Animals; Cell Line; Drug Synergism; Glioma; Guanidine; Guanidines; Halothane; Ion Channel | 1985 |