Page last updated: 2024-10-28

guanidine and Glioma

guanidine has been researched along with Glioma in 13 studies

Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0."7.66Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983)
"Studies were conducted using a novel in vitro approach to investigate the efficacy of acetamidine hydrochloride (ACE) and guanidine hydrochloride (GUAN), previously shown to block gramicidin D (GRAM) channels in artificial membranes, in preventing the toxic effects of GRAM in NG108-15 (neuroblastoma x glioma hybrid) cells."3.70Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine. ( Doebler, JA, 1999)
"In the presence of substance P (SP; 10 microM), serotonin (5-HT; 1 microM) triggered a cation permeability in cells of the hybridoma (mouse neuroblastoma x rat glioma) clone NG 108-15 that could be assessed by measuring the cell capacity to accumulate [14C]guanidinium for 10-15 min at 37 degrees C."3.68Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P. ( Emerit, MB; Fattaccini, CM; Hamon, M; Riad, M, 1993)
"Substance P at micromolar concentrations enhances the uptake of [14C]guanidinium in neuroblastoma X glioma hybrid cells, an effect which most likely indicates activation of Na+ permeability."3.67Characterization of a substance P receptor activating a cation permeability in neuronal cell lines. ( Hamprecht, B; Reiser, G, 1988)
"Both substance P and, to a lesser degree, serotonin activate cation permeability in neuroblastoma x glioma hybrid cells, as determined by measurement of [14C]guanidinium uptake."3.67Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line. ( Hamprecht, B; Reiser, G, 1989)
" Therefore, the veratridine- (or aconitine-)stimulated influx of [14C]guanidinium in neuroblastoma x glioma hybrid cells was measured to characterize the Na+ ionophore of these cells."3.66Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines. ( Günther, A; Hamprecht, B; Reiser, G, 1983)
"Substance P stimulated the uptake of guanidinium in neuroblastoma X glioma hybrid cells and neuroblastoma cells but not in polyploid glioma cells."3.66Substance P enhances cation permeability of neuronal cell lines. ( Folkers, K; Hamprecht, B; Reiser, G, 1982)
"Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0."3.66Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19908 (61.54)18.7374
1990's3 (23.08)18.2507
2000's0 (0.00)29.6817
2010's1 (7.69)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Márquez, M1
Olausson, KH1
Alaiya, A1
Nilsson, S1
Meurling, L1
Holmberg, AR1
Johansen, ML1
Gao, Y1
Hutnick, MA1
Craig, SEL1
Pokorski, JK1
Flask, CA1
Brady-Kalnay, SM1
Reiser, G6
Günther, A2
Hamprecht, B6
Folkers, K1
Emerit, MB1
Riad, M1
Fattaccini, CM1
Hamon, M2
Cappelli, A1
Anzini, M1
Vomero, S1
Mennuni, L1
Makovec, F1
Doucet, E1
Bruni, G1
Romeo, MR1
Menziani, MC1
De Benedetti, PG1
Langer, T1
Doebler, JA1
Tas, PW2
Kress, HG2
Koschel, K2

Other Studies

13 other studies available for guanidine and Glioma

ArticleYear
Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells.
    Investigational new drugs, 2022, Volume: 40, Issue:3

    Topics: Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioblastoma;

2022
Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo.
    Analytical chemistry, 2017, 06-06, Volume: 89, Issue:11

    Topics: Animals; Contrast Media; Glioma; Guanidine; Heterografts; Humans; Mice; Molecular Imaging; Neoplasms

2017
Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines.
    Journal of neurochemistry, 1983, Volume: 40, Issue:2

    Topics: Animals; Atropine; Calcium; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; Ki

1983
Substance P enhances cation permeability of neuronal cell lines.
    Regulatory peptides, 1982, Volume: 5, Issue:1

    Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels;

1982
Strychnine and local anesthetics block ion channels activated by veratridine in neuroblastoma x glioma hybrid cells.
    FEBS letters, 1982, Jul-05, Volume: 143, Issue:2

    Topics: Anesthetics, Local; Animals; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; K

1982
Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport.
    Pflugers Archiv : European journal of physiology, 1983, Jun-01, Volume: 397, Issue:4

    Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels;

1983
Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P.
    Journal of neurochemistry, 1993, Volume: 60, Issue:6

    Topics: Animals; Benzamides; Biological Transport; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Het

1993
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
    Journal of medicinal chemistry, 1998, Feb-26, Volume: 41, Issue:5

    Topics: Animals; Benzene; Binding Sites; Glioma; Guanidine; Mice; Models, Molecular; Molecular Structure; Ne

1998
Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine.
    Cell biology and toxicology, 1999, Volume: 15, Issue:5

    Topics: Amidines; Animals; Anti-Bacterial Agents; Drug Interactions; Electric Impedance; Electrophysiology;

1999
Characterization of a substance P receptor activating a cation permeability in neuronal cell lines.
    European journal of pharmacology, 1988, Jan-19, Volume: 145, Issue:3

    Topics: Glioma; Guanidine; Guanidines; Hybrid Cells; Neuroblastoma; Neurons; Receptors, Neurokinin-1; Recept

1988
Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line.
    Brain research, 1989, Feb-06, Volume: 479, Issue:1

    Topics: Catecholamines; Cations; Cell Line; Cell Membrane Permeability; Drug Interactions; Glioma; Guanidine

1989
The sodium channels of the neuroblastoma x glioma 108 CC 15 hybrid cell change their sensitivity for volatile and local anesthetics upon continuous passage.
    Journal of neural transmission, 1989, Volume: 76, Issue:2

    Topics: Anesthetics; Animals; Glioma; Guanidine; Guanidines; Halothane; Hybridomas; Isoflurane; Neuroblastom

1989
Halothane inhibits the neurotoxin stimulated [14C]guanidinium influx through 'silent' sodium channels in rat glioma C6 cells.
    FEBS letters, 1985, Mar-25, Volume: 182, Issue:2

    Topics: Aconitine; Animals; Cell Line; Drug Synergism; Glioma; Guanidine; Guanidines; Halothane; Ion Channel

1985