guanidine has been researched along with Glial Cell Tumors in 13 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0." | 7.66 | Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983) |
| "Studies were conducted using a novel in vitro approach to investigate the efficacy of acetamidine hydrochloride (ACE) and guanidine hydrochloride (GUAN), previously shown to block gramicidin D (GRAM) channels in artificial membranes, in preventing the toxic effects of GRAM in NG108-15 (neuroblastoma x glioma hybrid) cells." | 3.70 | Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine. ( Doebler, JA, 1999) |
| "In the presence of substance P (SP; 10 microM), serotonin (5-HT; 1 microM) triggered a cation permeability in cells of the hybridoma (mouse neuroblastoma x rat glioma) clone NG 108-15 that could be assessed by measuring the cell capacity to accumulate [14C]guanidinium for 10-15 min at 37 degrees C." | 3.68 | Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P. ( Emerit, MB; Fattaccini, CM; Hamon, M; Riad, M, 1993) |
| "Substance P at micromolar concentrations enhances the uptake of [14C]guanidinium in neuroblastoma X glioma hybrid cells, an effect which most likely indicates activation of Na+ permeability." | 3.67 | Characterization of a substance P receptor activating a cation permeability in neuronal cell lines. ( Hamprecht, B; Reiser, G, 1988) |
| "Both substance P and, to a lesser degree, serotonin activate cation permeability in neuroblastoma x glioma hybrid cells, as determined by measurement of [14C]guanidinium uptake." | 3.67 | Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line. ( Hamprecht, B; Reiser, G, 1989) |
| " Therefore, the veratridine- (or aconitine-)stimulated influx of [14C]guanidinium in neuroblastoma x glioma hybrid cells was measured to characterize the Na+ ionophore of these cells." | 3.66 | Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines. ( Günther, A; Hamprecht, B; Reiser, G, 1983) |
| "Substance P stimulated the uptake of guanidinium in neuroblastoma X glioma hybrid cells and neuroblastoma cells but not in polyploid glioma cells." | 3.66 | Substance P enhances cation permeability of neuronal cell lines. ( Folkers, K; Hamprecht, B; Reiser, G, 1982) |
| "Veratridine induces membrane potential oscillations in non-excitable glioma cells, which are not affected by ouabain (2 mM) or by D600 (0." | 3.66 | Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport. ( Hamprecht, B; Reiser, G, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Márquez, M | 1 |
| Olausson, KH | 1 |
| Alaiya, A | 1 |
| Nilsson, S | 1 |
| Meurling, L | 1 |
| Holmberg, AR | 1 |
| Johansen, ML | 1 |
| Gao, Y | 1 |
| Hutnick, MA | 1 |
| Craig, SEL | 1 |
| Pokorski, JK | 1 |
| Flask, CA | 1 |
| Brady-Kalnay, SM | 1 |
| Reiser, G | 6 |
| Günther, A | 2 |
| Hamprecht, B | 6 |
| Folkers, K | 1 |
| Emerit, MB | 1 |
| Riad, M | 1 |
| Fattaccini, CM | 1 |
| Hamon, M | 2 |
| Cappelli, A | 1 |
| Anzini, M | 1 |
| Vomero, S | 1 |
| Mennuni, L | 1 |
| Makovec, F | 1 |
| Doucet, E | 1 |
| Bruni, G | 1 |
| Romeo, MR | 1 |
| Menziani, MC | 1 |
| De Benedetti, PG | 1 |
| Langer, T | 1 |
| Doebler, JA | 1 |
| Tas, PW | 2 |
| Kress, HG | 2 |
| Koschel, K | 2 |
13 other studies available for guanidine and Glial Cell Tumors
| Article | Year |
|---|---|
Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells.
Topics: Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioblastoma; | 2022 |
Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo.
Topics: Animals; Contrast Media; Glioma; Guanidine; Heterografts; Humans; Mice; Molecular Imaging; Neoplasms | 2017 |
Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines.
Topics: Animals; Atropine; Calcium; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; Ki | 1983 |
Substance P enhances cation permeability of neuronal cell lines.
Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; | 1982 |
Strychnine and local anesthetics block ion channels activated by veratridine in neuroblastoma x glioma hybrid cells.
Topics: Anesthetics, Local; Animals; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; K | 1982 |
Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport.
Topics: Animals; Biological Transport; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; | 1983 |
Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P.
Topics: Animals; Benzamides; Biological Transport; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Het | 1993 |
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
Topics: Animals; Benzene; Binding Sites; Glioma; Guanidine; Mice; Models, Molecular; Molecular Structure; Ne | 1998 |
Gramicidin toxicity in NG108-15 cells: protective effects of acetamidine and guanidine.
Topics: Amidines; Animals; Anti-Bacterial Agents; Drug Interactions; Electric Impedance; Electrophysiology; | 1999 |
Characterization of a substance P receptor activating a cation permeability in neuronal cell lines.
Topics: Glioma; Guanidine; Guanidines; Hybrid Cells; Neuroblastoma; Neurons; Receptors, Neurokinin-1; Recept | 1988 |
Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line.
Topics: Catecholamines; Cations; Cell Line; Cell Membrane Permeability; Drug Interactions; Glioma; Guanidine | 1989 |
The sodium channels of the neuroblastoma x glioma 108 CC 15 hybrid cell change their sensitivity for volatile and local anesthetics upon continuous passage.
Topics: Anesthetics; Animals; Glioma; Guanidine; Guanidines; Halothane; Hybridomas; Isoflurane; Neuroblastom | 1989 |
Halothane inhibits the neurotoxin stimulated [14C]guanidinium influx through 'silent' sodium channels in rat glioma C6 cells.
Topics: Aconitine; Animals; Cell Line; Drug Synergism; Glioma; Guanidine; Guanidines; Halothane; Ion Channel | 1985 |